, Dawson P.
, Delehanty J.
, Deschamps J.
, Gemmill K.
, Huston A.
, Medintz I.
, Oh E.
, Stewart M.
, Susumu K.
, US Naval Research Laboratory, US
Semiconductor CdSe/Zn quantum dots are ideal materials for biological imaging due to their superior optical properties over fluorescent proteins and organic dyes. However, cytosolic cellular delivery of quantum dots has been hindered by endosomal sequestration [...]
When administered in vivo lipid nanoparticles (NPs) are immediately covered by a rich protein layer, known as “protein corona” that changes the size, aggregation state, and interfacial properties of the NP, giving it a biological [...]
We studied a panel of thermally sensitive amino-esters and amino-carbonates to evaluate their cyclization rates on heating. After analyzing the influence of chain length, steric factors, gem-dimethylation and additional functionalities, we have determined which ester [...]
, Boggs N.
, Brandacher G.
, Calderon-Colon X.
, Fuller B.
, Garza L.
, Le H.
, Nelson A.
, Patchan M.
, Patrone J.
, Sarkar K.
, Theodore M.
, The Johns Hopkins University Applied Physics Laboratory, US
Burn injuries, trauma, and surgical procedures result in complex wounds, which can lead to pain, infection, and scarring. Management of complex wounds remains a critical challenge for the medical community and effective, localized treatments are [...]
Cancer is always the leading cause of deaths in worldwide. The aim of this research is to develop a new generation of chemotherapeutic drugs with both photothermal activated drug release and MRI diagnostic function. Carbon [...]
The aim of this research was to develop a novel contrast agent with magnetic resonance (MR) imaging, fluorescent imaging and drug encapsulation functionalities. The zinc oxide (ZnO) nanoparticles and superparamagnetic iron oxide (Fe3O4) nanoparticleswas prepared [...]
In this study, PpIX was loaded in the shell of silica hollow sphere with the expectation that PpIX-loaded silica hollow spheres (PpIX-SHS) might be employed as a PDT agent with ultrasound image contrast. The PpIX-loaded [...]
To better understand the complex communication pathways of the tumor microenvironment, and therefore better design and develop therapies and diagnostics for cancers, experimental methods of probing cellular communication at a single to multi-cell level are [...]
Here, we have studied the effect of cholesterol on the transfection efficiency (TE) of cationic liposomes made of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and dioleoylphosphocholine (DOPC) in Chinese hamster ovary (CHO) cells. We held the charge of the [...]
CSIRO has developed thermoresponsive polymers for encapsulation and sustianed release of bioactives. They are stable aqueous solutions over 24 months, easily pass through a 25 gauge needle at room temperature and immediately gel into a [...]
Traditionally, a drug is administered initially at a higher dosage so as to repeat the next dose after several hours or days. This, besides being un-economical, results in side effects. Recently, there has been an [...]
There are many types of retinal disease which vary widely, with some being easier to treat than others. One such example is Age-Related Macular Degeneration (AMD) which is the largest cause of blindness for those [...]
Disulfide-containing HA dodecyl conjugates (HA-SS-DDTs) were synthesized using the facile thiol-exchange reaction as the carrier for intracellular delivery of doxorubicin (DOX). Owing to its amphiphilicity, HA-SS-DDT could form self-assembled nanoparticles in an aqueous condition. The [...]
A critical component to the prevention of the sexual transmission of HIV is adherence to the prevention modality. We have conjugated nucleoside-reverse transcriptase inhibitors (NRTIs) to a biocompatible polymer, PLGA using an amide bond. We [...]
In the near future, novel vaccines will be needed, particularly nanoparticles-based vaccine formulations for figthing problematic infectious diseases like tuberculosis, AIDS/ HIV or malaria and also cancers. Here, we described the development of versatile chemical [...]
Due to their ability to suppress the activity of autoreactive cells, “natural” CD4+ CD25high FoxP3+ T cells (Treg) are important drug targets for autoimmune diseases and malignancies. Immunological studies are revealing a growing subset of [...]
It has been shown that the morphology of nanomaterials greatly impacts the pharmacokinetic profile of the material, with larger micronscale fibril-like objects having longer circulation times while smaller nanomaterials show a greater rate of internalization [...]
Several supramolecular architectures on the nanoscale have become important candidates for potential applications in nanomedicine, particularly for drug, dye, and gene delivery. Out of various conceptual extensions for the development of such molecular objects, our [...]
The CaCO3 nanoparticles were derived from egg shells using sonochemical and mechanochemical methods. The glycerol and acetic acid were used as solvents in this process to avoid other toxic solvents. These nanoparticles were loaded with [...]
Superparamagnetic iron oxide nanoparticles (SPIONs) have become increasingly attractive materials in the field of Nano / Nano-biotechnology due to their potential applications in heteogeneious catalysis [1, 2], nanomedicine such as drug delivery [3, 4], cell [...]
In this presentation, we will talk about a unique nanoparticle-imaging-delivery platform developed at NVIGEN, Inc. for enhanced cancer therapeutic applications. Our proprietary nanoparticle-imaging-delivery (NID™) technology is a hybrid platform comprised of an intrinsically signal-generating component [...]
Since the discovery of RNA interference, many efforts have been made to broaden perspectives of small interfering RNA (siRNA) in research and clinical work. siRNA shows a specific and effective gene silencing activity through a [...]
The emergence of drug-resistant cancer cells together with the toxicity side effect of chemotherapy agents are the major obstacle in cancer treatment. We focused on providing a new pattern of protein-based nanoparticle as drug delivery [...]
In the present work we investigated the electrostatic self-assembly of nanoparticles of Lyz and different alginates (Alg A Mw~4kD and M/G~1.42 or Alg B Mw~7kD and M/G~5.00)to establish a relationship between the alginate structure and [...]
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Published: May 12, 2013
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topicss: Biomaterials, Materials for Drug & Gene Delivery