Texier I. – TechConnect Briefs

Development and Validation of Characterization Methods for Lipidots® Multifunctional Platform: a Step forward Industrial Transfer

Boisseau P., Caputo F., Ciancone M., Couffin A.C., Escudé M., Jary D., Laffont C., Navarro F.P., Texier I., Varache M., CEA-LETI, FR

For eight years, our research group has been developing lipid nanocarriers, known as Lipidots®, as a multifunctional platform for medical applications. A wide range of active pharmaceutical ingredients (APIs) and contrast imaging agents has been [...]

Nanoemulsion with tuneable lipid shell dedicated to targeted delivery of small and biomacro- molecules

Auzély-Velty R., Bruniaux J., Couffin A.C., Courant T., Fournier A., Gidrol X., Hoang A., Martin C., Mittler F., Navarro F., Sulpice E., Texier I., Commissariat à l'Energie Atomique et aux Energies Alternatives, FR

Lipid nanocarriers are considered as suitable carriers to formulate lipophilic drugs, transport them and also deliver more specifically at appropriate biological sites. Based on oil-in-water template emulsion, we have been developing nanodroplets as drug or [...]

Cationic lipid nanoemulsions for RNAi screening

Bruniaux J., Gidrol X., Mittler F., Navarro F.P., Sulpice E., Texier I., CEA/LETI/MINATEC, FR

Since the discovery of RNA interference, many efforts have been made to broaden perspectives of small interfering RNA (siRNA) in research and clinical work. siRNA shows a specific and effective gene silencing activity through a [...]

Lipid nanoparticles for enhancing immune responses to protein antigens

Courant T., Hoang A., Marche P.N., Mittler F., Navarro F.P., Reynaud H.L., Texier I., Villiers C., CEA/LETI/MINATEC, FR

In the near future, novel vaccines will be needed, particularly nanoparticles-based vaccine formulations for figthing problematic infectious diseases like tuberculosis, AIDS/ HIV or malaria and also cancers. Here, we described the development of versatile chemical [...]

Lipid nanoparticles: tumor-targeting nanocargos for drug and contrast agent delivery

Bibette J., Boisgard R., Boisseau P., Coll J.L., Couffin A.C., Delmas T., Dufort S., Fraichard A., Gravier J., Heinrich E., Mérian J., Navarro F., Tavitian B., Texier I., Thomann J.S., CEA-Grenoble, FR

A new technology for the encapsulation of lipophilic molecules -both drugs and contrast agents dedicated to chemotherapy, phototherapy, or fluorescence imaging in oncology- has been developed, based on oil-in-water nanoemulsions. Thorough physico-chemical characterizations of the [...]