Drug Delivery


Nanoconjugates of poly(malic acid) with functional modules for drug delivery

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Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and [...]

Functional Stimuli-Responsive Nanogel-particles for Oral Peptide Delivery: Preparation, Drug-Release Behaviors and in Vitro Cellular Interaction

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The present study involves preparation and evaluation of novel core-shell nanoparticles (CSNPs) consisting of thermo-responsive poly(N-isopropylacrylamide) (p(NIPAAm)) hydrogel core with pH-responsive poly(methacrylic acid-grafted-poly(ethylene glycol)) (p(MAA-g-EG)) shell layer as a carrier for oral peptide delivery. The [...]

Interaction between Artificial Mucin Layer and Stimuli-Responsive Nanogel Particles for the Oral Peptide Delivery Observed in Simulated Intestinal Solutions by Using Colloid Probe AFM Method

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In order to characterize and control the adhesive behaviors of nanometer scaled stimuli-responsible gel particles designed for oral peptide delivery, their interaction with artificial mucin layer in the small intestinal solutions was determined by the [...]

Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 7, 2006
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 0-9767985-7-3