Interaction between Artificial Mucin Layer and Stimuli-Responsive Nanogel Particles for the Oral Peptide Delivery Observed in Simulated Intestinal Solutions by Using Colloid Probe AFM Method

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In order to characterize and control the adhesive behaviors of nanometer scaled stimuli-responsible gel particles designed for oral peptide delivery, their interaction with artificial mucin layer in the small intestinal solutions was determined by the [...]

Functional Stimuli-Responsive Nanogel-particles for Oral Peptide Delivery: Preparation, Drug-Release Behaviors and in Vitro Cellular Interaction

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The present study involves preparation and evaluation of novel core-shell nanoparticles (CSNPs) consisting of thermo-responsive poly(N-isopropylacrylamide) (p(NIPAAm)) hydrogel core with pH-responsive poly(methacrylic acid-grafted-poly(ethylene glycol)) (p(MAA-g-EG)) shell layer as a carrier for oral peptide delivery. The [...]