Chitosan Nanoparticles for the Effective Vaccine Delivery System

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There are four genes of S, C, X, P in HV DNA. S gene has the pre-S region composed of pre-S1 and pre-S2 as an encoding gene of surface antigen. C gene is in the precore region for the encoding of core protein(HBcAg). Hepatitis virus(Hv) is the liver affinity DNA virus as a kind of hepadna virus has 42 nm diameter and no cell denaturalization phenomenon. Outer membrane of the virus consist of hepatitis surface antigen(HBsAg) and center is composed of HV DNA and hepatitis B core antigen(HBcAg). All of the infants have to be prescribed by three consecutive injection of hepatitis vaccine just after his birth adults are also prescribed by an intra muscular injection every five years. Recently, it is very mortal that people over 8 % get infected with chronic hepatitis as increasing trend and consequently leaded to the death because of a complication arises of cirrhosis and liver cancer. In this study biodegradable polymer’s derivatives was synthesized and made to nanoparticles as a supporter of vaccine. The character of vaccine delivery body as its size and surface polarity was analyzed by AFM and Zeta potential. FT-IR, HPLC, atomic analyzer, and SEM for the development of effective drug delivery system.

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Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 7, 2006
Pages: 388 - 391
Industry sector: Medical & Biotech
Topicss: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 0-9767985-7-3