Exposure to nanoparticles collected in the Los Angeles basin in California leads to the up regulation to brain associated genes

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Direct evidence regarding brain tumors as a result of exposure to specific chemical agents and particulate air pollutants is limited. We wanted to determine the size of nanoparticles from Los Angeles basin in California, coarse [...]

Development of Nanoconjugate with Different Monoclonal Antibodies to Inhibit Molecular Targets Important for Tumor Angiogenesis

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Tumor cell-specific drug targeting is the major goal of nanotechnology-based platforms. A nanoconjugate Polycefin was synthesized for targeted delivery of antisense oligonucleotides and antibodies into tumors. The delivery of antisense oligonucleotides to α4 and β1 [...]

Nanoconjugates of poly(malic acid) with functional modules for drug delivery

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Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and [...]