Black K.L. – TechConnect Briefs

Molecular Changes in Rat Brain Due to Air Nano Pollution

Ljubimova J.Y., Gangalum P.R., Portilla-Arias J., Patil R., Konda B., Paff M., Markman J., Inoue S., Espinoza A., Chesnokova A., Kleinman M., Holler E., Black K.L., Cedars-Sinai Medical Center, US

Air pollution has been found to cause neurodegeneration, deposition of heavy metals & beta amyloid plaques in the brain. Air pollution constitutes of nanopollutant of different sizes that can enter the system and cause diseases. [...]

Polymalic acid-based nanodrugs: Anti-tumor efficacy and host compatibility

Holler E., Ding Hui, Patil R., Portilla J., Inoue S., Gangulum P., McNeil S.E., Patri A., Dobrovolskaia M.A., Black K.L., Ljubimova J.Y., Cedars-Sinai Medical Center, US

A polyanionic drug carriers is presented that penetrates biobarriers and targets molecular cancer markers of human breast and brain cancer. The carrier platform is poly(beta-L-malic acid) (PMLA), which is highly water soluble and biodegradable to [...]

Exposure to nanoparticles collected in the Los Angeles basin in California leads to the up regulation to brain associated genes

Ljubimova J.Y., Kleinman M.T., Khazenzon N.M., Fujita M., Rudenkyy S., Ospital J., Wallerstein B., Meacher D., Gookin G., Salazar K., Black K.L., Cedars-Sinai Medical Center, US

Direct evidence regarding brain tumors as a result of exposure to specific chemical agents and particulate air pollutants is limited. We wanted to determine the size of nanoparticles from Los Angeles basin in California, coarse [...]

Development of Nanoconjugate with Different Monoclonal Antibodies to Inhibit Molecular Targets Important for Tumor Angiogenesis

Fujita M., Khazenzon N.M., Lee B-S, Holler E., Black K.L., Ljubimova J.Y., Cedars-Sinai Medical Center, US

Tumor cell-specific drug targeting is the major goal of nanotechnology-based platforms. A nanoconjugate Polycefin was synthesized for targeted delivery of antisense oligonucleotides and antibodies into tumors. The delivery of antisense oligonucleotides to α4 and β1 [...]

Nanoconjugates of poly(malic acid) with functional modules for drug delivery

Ljubimova J.Y., Fujita M., Lee B-S, Khazenzon N.M., Wachsmann-Hogiu S., Farkas D.L., Black K.L., Holler E., Cedars-Sinai Medical Center, US

Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and [...]