One-step Target Protein detection from Whole Blood in a Lab-on-a-Disc

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We report a fully integrated, one-step Lab-on-a-Disc for detecting target protein from whole blood utilizing centrifugal microfluidics, so called “Immunoassay Lab-on-a-Disc”. The design principle is the microbead-based sandwich ELISA on the Disc. The microbeads are [...]

Development of Nanoconjugate with Different Monoclonal Antibodies to Inhibit Molecular Targets Important for Tumor Angiogenesis

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Tumor cell-specific drug targeting is the major goal of nanotechnology-based platforms. A nanoconjugate Polycefin was synthesized for targeted delivery of antisense oligonucleotides and antibodies into tumors. The delivery of antisense oligonucleotides to α4 and β1 [...]

One-step Pathogen Specific DNA Extraction from Whole Blood On a Centrifugal Microfluidic Device

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We report a fully integrated pathogen specific DNA extraction device utilizing centrifugal microfluidics on a polymer based CD platform. Using the innovative Laser Irradiated Ferrowax Microvalves (LIFM) together with the rapid cell lysis method using [...]

Nanoconjugates of poly(malic acid) with functional modules for drug delivery

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Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and [...]