Papers:
Nanotechnology for Drug Delivery: An Overview
Nanotechnology is expected to have a revolutionary impact on biology and medicine. In this paper, I will discuss the role of nanotechnology in development of site-specific drug delivery systems. Polymeric nanoparticles, lipid nanosystems, and self-assembling [...]
In Vivo Tracking of Liposomes Using CT and MR Imaging
Currently, there are limited methods available for longitudinal and non-invasive in vivo assessment of the transport kinetics of carrier-based therapeutics, such as those relying on liposomes. A viable strategy to non-invasively track the carrier in [...]
Nanoconjugates of poly(malic acid) with functional modules for drug delivery
Ljubimova J.Y., Fujita M., Lee B-S, Khazenzon N.M., Wachsmann-Hogiu S., Farkas D.L., Black K.L., Holler E., Cedars-Sinai Medical Center, US
Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and [...]
Development of a Novel Triblock Copolymer Therapeutic Nanoreactor
Currently chemotherapy is one of the major strategies to treat cancer patients. It is however limited by several drawbacks such as low bioavailability of chemotoxins, low drug concentrations at the tumor site, systemic toxicity, lack [...]
Shell Cross-Linked Nanoparticle Based on Poly(e-caprolactone)-Poly(ethylene glycol) for Photosensitizer Delivery
Photodynamic therapy (PDT) is a novel photochemical process for producing localized tissue necrosis, which involves the activation of a photosensitizing drug in the target tissue with light of a specific wavelength matched to an absorption [...]
Formulation Optimization for the Nanoparticles-in-Microsphere Hybrid Oral Delivery Systems Using Factorial Design
The objective of the present study was to optimize the processing parameters for nanoparticles-in-microsphere hybrid system for oral delivery (NiMOS) and to mathematically relate the process parameters with the selected attribute (particle size) of the [...]
Cationic Nanoparticles based on pH Responsive Polyion Complexes containing Plasmid GFP DNA
Cationic nanoparticles were formulated from a polycationic Polyhydroxylamine (PT) with low pKa and polyanionic PolyAcrylic Acid (PA) that form binary polyelectrolyte complexes (PECs). Particles spontaneously form on component mixing with sizes between 80-700nm and particle [...]
Microscopic Mechanism of Sonoporation
This paper will expand on our recent paper in Nature Physics (November 2005) and will show that the initial observations can be extended from rigid albumin systems to flexible lipid based microbubbles also. We will [...]
A Novel Biodegradable System Based on BSA/PCL Core-shell Structured Nanofibers for Controlled Drug Delivery
Electrospun core-shell structured nanofibers encapsulating BSA were explored as a potential drug delivery model in a biological system in present study. These nanofibers were prepared by coaxial electrospinning method with poly (caprolactone) (PCL) as the [...]
Synergistic Release of DNA from pH Responsive Polyion Complexes (PICs)
Polyelectrolyte complexes based on an outer layer of cationic polyhydroxylamine (PT) were prepared on carboxylated microparticles pretreated with polyamine (A) and a middle layer of Polyacrylic Acid (PA). A synergistic effect between PT and PA [...]
Synthesis and Photodynamic Efficacy of PAMAM-Photosensitiser Conjugates in Vitro
Peng C.L., Lai P.S., Lai T.-Y., Chiu C.H., Chang C-C, Lai P.S., Lai T.-Y., Shieh M.J., National Taiwan University, TW
Starburst polyamidoamine (PAMAM) dendrimer is a new class of highly branched spherical polymer. Covalent attachment of porphyrin to PAMAM dendrimer may alter the pharmacokinetics, cell targeting, and photophysical properties of photosensitizer. We investigated the uptake, [...]
Chitosan Nanoparticles for the Effective Vaccine Delivery System
There are four genes of S, C, X, P in HV DNA. S gene has the pre-S region composed of pre-S1 and pre-S2 as an encoding gene of surface antigen. C gene is in the [...]
Functional Stimuli-Responsive Nanogel-particles for Oral Peptide Delivery: Preparation, Drug-Release Behaviors and in Vitro Cellular Interaction
The present study involves preparation and evaluation of novel core-shell nanoparticles (CSNPs) consisting of thermo-responsive poly(N-isopropylacrylamide) (p(NIPAAm)) hydrogel core with pH-responsive poly(methacrylic acid-grafted-poly(ethylene glycol)) (p(MAA-g-EG)) shell layer as a carrier for oral peptide delivery. The [...]
Construction of Enzymosomes: Optimization of Coupling Parameters
Vale C.A., Corvo M.L., Martins L.C.D., Martins M.B.F., Marques C.R., Storm G., Cruz M.E.M., Martins L.C.D., Martins M.B.F., Laboratorio Nacional de Engenharia, Tecnologia e Inovacao, IP, PT
Different strategies can be used to improve carrier mediated delivery of therapeutic proteins. The incorporation of therapeutic enzymes into polymeric carriers [1], into aqueous space of lipid vesicles [2] or lipid-detergent vesicles [3, 4] or [...]
Sensing and Plotting Single Molecule Binding Events with the Atomic Force Microscope
SPM/AFM (scanning probe microscopy/atomic force microscopy) offers many unique advantages to the study of biological process at the nanometer scale. ASM/AFM allows scientists to visualize, probe, and analyze the structure of biological molecules in their [...]
Dicationic gemini surfactant gene delivery complexes contain cubic-lamellar mixed polymorphic phase
The characterization of structural properties of novel dicationic (gemini) surfactant-based DNA complexes as micro/nano-scale self-assembling delivery systems for cutaneous gene therapy is described and discussed as related to measured transfection efficiencies. Previous small-angle x-ray scattering [...]
Interaction between Artificial Mucin Layer and Stimuli-Responsive Nanogel Particles for the Oral Peptide Delivery Observed in Simulated Intestinal Solutions by Using Colloid Probe AFM Method
Kamiya H., Yoshimura M., Tsukada M., Ichikawa H., Fukumori Y., Tokyo University of Agriculture and Technology, JP
In order to characterize and control the adhesive behaviors of nanometer scaled stimuli-responsible gel particles designed for oral peptide delivery, their interaction with artificial mucin layer in the small intestinal solutions was determined by the [...]
Preparation and Characterization of Various Nanofluids
Williams W.C., Bang I.C., Forrest E., Hu L.W., Buongiorno J., Massachusetts Institute of Technology, US
As part of an effort to evaluate water-based nanofluids for nuclear applications, preparation and characterization has been performed for nanofluids being considered for MIT’s nanofluid heat transfer experiments. Three methods of generating these nanofluids are [...]
Economic and Environmental Tradeoffs in SWNT Production
Assessment of economic and environmental attributes of nanomanufacturing during process development has significant potential to contribute to the quality and effectiveness of the processes, and will lead to development of competitive, safe and environmentally responsible [...]
Nanotechnology and the Water Market: Applications and Health Effects
Nanotechnology has an enormous potential for creating cost-effective, simple, and efficient tools for addressing water supply challenges, while preventing the creation of potentially toxic by-products. Applications include water disinfection and filtration, real-time and remote monitoring, [...]
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 7, 2006
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 0-9767985-7-3