We have recently developed a non-toxic, topically applied biosensor using solid lipid nanoparticles (SLN). This diagnostic platform is currently designed to continuously monitor hydrogen peroxide levels in skin. Overproduction of hydrogen peroxide is implicated in [...]
In this study, the importance of pre-concentration is clearly demonstrated for the covalent immobilization of various proteins to magnetic nanoparticles through mild carbodiimide activation. Additionally, the covalently biofunctionalized magnetic nanoparticles are employed in a double-bead [...]
The detection of acetone in the human breath is a promising method for the noninvasive diagnosis and monitoring of diabetes. Here, a portable and highly selective acetone-sensor was developed by direct flame synthesis and deposition [...]
Magnetic nanosensors (MRnS) offer multiple benefits that can be used to design sensitive and robust diagnostic tools. High sensitivity, stability, and ease of surface modification make this approach a strong contender against the more commonly [...]
The conjugation of targeting ligands to iron oxide nanoparticles has achieved the development of specific assays for the detection of biomedical targets through magnetic relaxation. However, limited studies investigated how the nanoparticle valency modulates the [...]
This work presents a simple method of combining macro connectors with pre-fabricated nanovire chips. This design offers a unique ease and rapidity of connecting the nanowires with the connectors without using imaging and external aid [...]
We introduce and demonstrate the capabilities of a novel integrated optoelectronic-microfluidic sensor array that can rapidly distinguish millions of, trace level volatile chemicals based on their spectroscopic fingerprints inside flexible optofluidic channels. The system consists [...]
I will present results from my research group on nanopore-based single-biomolecule sensor with particular focus on electrode/nanopore structures. To this end, electrochemical concepts can be used for fabrication purposes, as well as for increased temporal [...]
A DNA senor using silica nanotubes (SNTs) was developed to detect some bacteria by barcoded SNTs. The SNTs were fabricated using anodic aluminum oxide (AAO) templates by the surface sol-gel method. To recognize each DNA [...]
An ideal point-of-care device would incorporate the simplicity and reliability of a lateral flow assay with a microfluidic device. Our system consists of self-priming microfluidics with sealed conjugate pads of reagent delivery and an absorbent [...]
Rapid and reliable monitoring of persistent organic pollutants (POPs) is very important to prevent their harmful effect on environment. In this study, microfluidic device to detect polychlorinated biphenyls (PCBs), which are well known insecticide, was [...]
In this study, we report on the rational design of a nano-complex that consists of gold nanoparticle (AuNP), antibody, oligonucleotides and horseradish peroxidase (HRP) for the detection of pathogen. The AuNP was functionalized with a [...]
There exist three kinds of endocytosis; receptor mediated endocytosis, pinocytosis and phagocytosis. First, receptor-mediated endocytosis is essential for targeted gene/drug delivery to a specific cell type. Second, pinocytosis is the engulfing and digestion of dissolved [...]
In this work, we demonstrate novel nanoelectronics devices based on single-walled carbon nanotube field-effect transistor (NTFET) to probe the interactions between carbohydrates and their recognition proteins called lectins. These interactions are involved in a wide [...]
Single-walled carbon nanotubes (SWNTs) and their composites are ideal candidates for chemical and biological sensing application, due to their unique electronic, chemical and physical properties. Green tea, or more specifically its main antioxidant component, epigallocatechin [...]
Research is being performed to develop rapid and novel electrochemical biosensors for the detection of food pathogens at the US Army NSRDEC. The focus of the research is fiber based platforms to perform both capture [...]
Gold nanoparticles (GNP) and RGD peptide modified indium tin oxide (ITO) electrode was fabricated to enhance the electrochemical signals from neural stem cells (HB1.F3). ITO film is well-known transparent and conductive material suitable for both [...]
, Flanagan K.
, Gendra E.
, Harwood C.
, Hedley J.
, Keegan N.
, Ko Ferrigno P.
, McNeil C.J.
, Spoors J.
, Wipat A.
, Newcastle University, UK
It is now widely accepted that a combination of nanotechnology and engineering that harnesses the full potential of genomic information through real-time predictive, preventive, point-of-care healthcare provision will lead to the next technological revolution. However, [...]
, Branen A.L.
, Gibson C.M.
, Haler K.J.
, Hurdlicka P.J.
, Jabal J.
, Qiang Y.
, Rastogi S.K.
, Zhang H.
, University of Idaho, US
Silica coated Magnetic nanoparticles (SMNPs; SiO2/Fe3O4 + Fe2O3) were prepared by encapsulation of iron oxide NPs with silica dioxide using the sol-gel method and characterized through transmission and scanning electron microscopic imaging, magnetic hysteresis and [...]
A highly sensitive and selective H2S gas sensor has been developed by deposited a SnO2 thin film on an alumina substrate with a spin-coated method. This SnO2 sensing film was be made by a sol-gel [...]
To meet the challenges of new genomic and proteomic applications, rapid and sensitive analysis of large numbers of interactions in parallel will be required. High-density microarrays are ideally suited for parallel multiplex screening of thousands [...]
Ordered arrays of nanostructures in metal films have been studied for practical miniaturization of SPR sensing and microfluidic integration. We report a nanostructure array that is designed to permit significantly enhanced Extraordinary Optical Transmission (EOT) [...]
Plasmonics is quickly becoming a dominant technology in the fields of novel optical devices employing new experimental capabilities of subwavelength metallic nanostructures. In combination with modern nanofabrication technologies which allows preparation of numerous regular patterns [...]
We report a novel design for the intermediary layer of surface plasmon resonance (SPR) devices that use high refractive index and high-transmittance zinc oxide (ZnO) dielectric layers to enhance the signal quality and improve the [...]
We demonstrated the surface plasmon grating coupled emission (SPGCE) from photo-excited organic layer covered with metal thin film on the corrugated substrate. Directional emissions corresponded to the resonant condition of surface plasmon modes on the [...]
we investigate an optimal separation condition regarding the gravitation, the hydrodynamic force and the n-DEP force acting on particles in the sorting platform since contribution of each force is the main parameter to determine SE. [...]
In this abstract, we describe a novel PEG-based, simple-to-fabricate, U-shaped micro-scale growth chamber, which allows cell trapping and forming into spheroids as well as culturing in the presence of a continuous perfusion flow, a long-term [...]
Accurate blood glucose monitoring is critical for diabetes patients to tightly control their diseases. For decades, blood glucose monitoring technology has relied on the use of reagents, including enzymes, mediators, and buffers. This monitoring technology [...]
Metallo-dielectric screens (IR screens) have been investigated from the visible to the THz spectral region for astronomy and remote sensing applications. These screens are made of periodic structure aim to invoke surface plasmon polariton (SPP) [...]
Surface enhanced Raman spectroscopy (SERS) is a powerful tool used for observing molecules and their structural properties, due to their ability to enhance the otherwise weak Raman scattering signals on a roughened metal surface or [...]
The use of nanopores to study DNA has been the topic of intense research over the past decade. Nanopores have been used to probe the structure and electro-physical properties of DNA. These studies have been [...]
To enable not only long sequence read but also high throughput in a DNA sequencer, the single molecule sequencing method based on direct observation of processive DNA polymerization is very promising. In this method, only [...]
The dominant absorption band at 395 nm of the green fluorescent protein (GFP) is attributed to the protonated form of the chromophore. Photo excitation forms an excited intermediate anion from this excited protonated form and [...]
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 13, 2011
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topicss: Chemical, Physical & Bio-Sensors, Diagnostics & Bioimaging