Fabrication of PEG Hydrogel Microstructures in Microfluidic System for Multicellular Spheroid Formation, Culturing and Analysis

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In this abstract, we describe a novel PEG-based, simple-to-fabricate, U-shaped micro-scale growth chamber, which allows cell trapping and forming into spheroids as well as culturing in the presence of a continuous perfusion flow, a long-term 3D cell culture can be achieved. We believe that it can provide a good platform for many liver spheroid-based studies and applications in the future.

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 13, 2011
Pages: 98 - 100
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topicss: Chemical, Physical & Bio-Sensors, Diagnostics & Bioimaging
ISBN: 978-1-4398-7138-6