Papers – Page 10 – TechConnect Briefs

Two-Dimensional Analysis of the Enhanced Magnetic Bioseparation in Microfluidic Systems

Shi Z., Sun J., Jia S., Zhang P., Xi'an Jiaotong University, CN

The separation of magnetically-labeled bioparticles in a microfluidic system is dependent on the characteristics of the particles and the carrier fluid as well as the external magnetic field. To discuss the influence of these factors, [...]

3-D electrode configuration for electrochemical impedance spectroscopy of bulk solution

Wang A., Koh D., Schneider P., Oh K.W., University at Buffalo, US

Abstract In this paper, a 3-D electrode configuration for electrochemical impedance spectroscopy (EIS) of a bulk solution was studied. Top- and bottom- electrode configuration, where two electrodes sandwich the sensing channel, was fabricated using the [...]

Deterministic Lateral Displacement (DLD): Finite element modeling and experimental validation for particle trajectory and separation

Pariset E., Berthier J., Révol-Cavalier F., Pudda C., Gosselin D., Navarro F., Icard B., Agache V., CEA-LETI, FR

In biotechnology and biology, deterministic lateral displacement (DLD) arrays are used to separate particles based on their size, such as cells, bacteria, parasites and exosomes. DLD is very promising for sample preparation purposes as it [...]

On the use of polymeric additives to promote plasma separation from whole blood in open microchannels

Lee E., Berthier J., Laurent P., Navarro F., Cubizolles M., CEA, FR

Polymers additives in whole blood are known to modify blood physical properties. For example, Dextran molecules usually accelerate the aggregation of re-suspended RBCs in Ringer solutions. In this work, we first investigate the effect of [...]

Self-navigating drug delivery nanovehicles driven by polyvalent multifunctional phages and their promiscuous proteins

Petrenko V.A., Gillespie J.W., Auburn University, US

Development of precision medicines acting specifically at the site of disease has been a long sought goal for the last century, starting from pioneering works of Paul Ehrlich, who suggested the concept of site-directed chemotherapeutics [...]

Enhancement of anticancer action of traditional (doxorubicin and cisplatin) and experimental (landomycin A) drugs by their delivery in vivo with novel C60-fullerene-based nanocarriers possessing innate ROS-modulating activity

Panchuk R., Prylutska S., Skorokhyd N., Lehka L., Skivka L., Hurmach V., Evstigneev M., Piosik J., Berger W., Prylutskyy Yu., Scharff P., Stoika R., Vari S., Institute of Cell Biology NAS of Ukraine, UA

Rapid development of multi-drug resistance of tumor cells to chemotherapy caused by the over-expression of specific ABC-transporter proteins and/or multiple defects in genes involved in cell cycle and apoptosis regulation in cancer cells frequently leads [...]

Cancer Nanomedicines: Challenges and Opportunities

Tamarkin L., CytImmune Sciences, Inc, US

The treatment of cancer remains an ever-growing problem. Treating solid tumors as a medical disease first, using the natural biology of tumors to reduce or eliminate tumors in situ, offers patients and the entire healthcare [...]

Modular Nanoparticle Probes for Personalized in Vitro and in Vivo Imaging of Cancer Cell Populations

Nallathamby P.D., Cowden-Dahl K., Roeder R.K., University of Notre Dame, US

The high mortality and poor prognosis for women diagnosed with ovarian cancer is mainly due to late diagnosis. Improved detection of primary tumors and recurrence after chemotherapy is, therefore, crucial to reduce ovarian cancer mortality [...]

Novel fluorescent nanoparticles for ultrasensitive identification of nucleic acids by optical methods

Westergaard Mulberg M., Taskova M., Okholm A., Kjems J., Astakhova K., University of Southern Denmark, DK

There have been an enormous interest in new amplification-free detection methods. A tremendous progress has been made in fluorescence based optical detection of biomolecules, which here resulted in the synthesis of novel ultra bright fluorescent [...]

Carcinoma cellular uptake, imaging, and targeting by RGDS- and TAT-conjugated upconversion and/or magnetic nanoparticles

Horák D., Kostiv U., Proks V., Jirák D., Institute of Macromolecular Chemistry AS CR, CZ

Specific targeting and in vivo visualization of cancer cells is of crucial importance for early detection and treatment of cancer. We have developed monodisperse poly(ethylene glycol) (PEG)-modified SiO2-coated Fe3O4 superparamagnetic nanoparticles [1] with size tuned [...]