University of Southern Denmark – TechConnect Briefs

Novel fluorescent nanoparticles for ultrasensitive identification of nucleic acids by optical methods

Westergaard Mulberg M., Taskova M., Okholm A., Kjems J., Astakhova K., University of Southern Denmark, DK

There have been an enormous interest in new amplification-free detection methods. A tremendous progress has been made in fluorescence based optical detection of biomolecules, which here resulted in the synthesis of novel ultra bright fluorescent [...]

Amplification-free liquid biopsy by fluorescence approach

Uhd J., Taskova M., Okholm A., Astakhova K., University of Southern Denmark, DK

Diagnostics of cancer associated ctDNA, BRAF V600E, KRAS G12D and KRAS G13D respectively. By the use of modern fluorescence microscopy and fluorescently labeled mutation specific LNA/DNA probes. Which resulted in a mutation specific detection.

Synthetic LNA/DNA Nano-scaffolds for Highly Efficient Diagnostics of Nucleic Acids and Autoimmune Antibodies

Astakhova I.K., University of Southern Denmark, DK

Herein we describe fluorescent oligonucleotides prepared by click chemistry between novel alkyne-modified locked nucleic acid (LNA) strands and a series of fluorescent azides for highly efficient homogeneous (all-in-solution) detection of nucleic acids and autoimmune antibodies. [...]

Modelling Coupled Motion of Electrons in Quantum Dots with Wetting Layers

Melnik R.V.N., Willatzen M., University of Southern Denmark, DK

The influence of wettin-layer states on quantum-dot states and vice-versa is examined numerically employing a one-band model for electroncs in the conduction band. This problem corresponds to the case where a few monolayer InAs grown [...]

Modelling Coupled Motion of Electrons in Quantum Dots with Wetting Layers

Melnik R.V.N., Willatzen M., University of Southern Denmark, DK

The influence of wettin-layer states on quantum-dot states and vice-versa is examined numerically employing a one-band model for electroncs in the conduction band. This problem corresponds to the case where a few monolayer InAs grown [...]