Materials for Drug & Gene Delivery

Spectrally-Selective Light-Induced Release from Gold-Coated Liposomes

Leung S.J., Romanowski M., University of Arizona, US

To address unmet medical needs in the area of controlled delivery, we recently presented liposome-supported plasmon resonant gold nanoshells. These composite structures are degradable into components of a size compatible with renal clearance, potentially enabling [...]

Plasmonic Nanobubbles for Intracellular Targeting and Gene Therapy

Lukianova-Hleb E., Wen J., Meteletsa L., Brenner M., Chang J., Lapotko D.O., Rice University, US

Intracellular molecular targeting (IMT) and gene transfection of eukaryotic cells is widely used for research and for developing gene cell therapy. However, the existing IMT methods lack selectivity, efficacy and safety when heterogeneous cell systems [...]

Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-Targeted Gelatin Nanoparticles

Xu J., Amiji M., Northeastern University, US

More than 32,000 patients are diagnosed with pancreatic cancer in the United States per year and the disease is associated with very high mortality. Although gene therapy has tremendous promise, the major challenge has been [...]

Sensitivity of Detection by Biological AFM for Gold-Labeled Liposomes at Human Coronary Artery Endothelial Cell (HCAEC) Membranes

Zaske A.M., Danila D., Queen M.C., Golunski E., Conyers J.L., University of Texas Health Science Center at Houston, US

Engineering of non-toxic nanoparticles for tissue-specific targeting has gained widespread attention this decade. Liposomes were one of the earliest classes of engineered nanoparticles to be utilized for the purpose of delivering drugs within the human [...]

A proof of concept: a model of targeted stealth nanoparticles that are stable and biocompatible for RNA interference in vivo to macrophages

Yusuf M.S., Miller A.D., Prata C.H., Imperial College Gene Therapies Centre, UK

Bringing together advances generated through the developing fields of bionanotechnology and gene therapy, and demonstrated through the ABCD model, we propose a biocompatible, stable, specific stealth lipoplex targeting macrophages, as proof of concept, which is [...]

An Intracranial Neurocompatible Nanocomposite Polymeric Device for the Chronic Management of AIDS Dementia Complex

Khan R.A., Harilall S-L., Pillay V., Choonara Y.E., du Toit L.C., Modi G., Naidoo D., Iyuke S., Integral University, IN

This study focused on the design, biometric simulation and development of a biodegradable Composite Intracranial Nano-enabled Device (CIND) for the intracranial delivery of zidovudine (AZT) in the treatment of AIDS Dementia Complex (ADC), a common [...]

Transformation of gold nanoparticles into effective gene silencing vectors by oligoethylene glycol passivation

Papasani M.R., Pokharel D., Giri A., Sai V.V.R., Hrdlicka P.J., Hill R.A., University of Idaho, US

Small interfering RNAs (siRNAs) are useful agents for gene knockdown. We have taken a systematic approach to investigate the use of GNP as delivery platforms for firefly luciferase (FFL) siRNAs and the effect of passivation [...]

The effect of Simvastatin Acid Loaded Photocurable Hyaluronic Acid Hydrogel for Bone Regeneration In vitro and In vivo

Bae M.S., Kim S.E., Na J.S., Kwon I.K., School of Dentistry, Kyung Hee University, KR

In the field of bone tissue engineering, various biomaterials have been developed in conjugation with bone inducing factors for bone tissue regeneration due to their distinct activities of osteoconductivity and osteoinductivity. In this study, we [...]

Modified glycol chitosan nanocarriers carry hydrophobic materials into tumours

Raza A., de-la Fuente M., Uchegbu I.F., Schätzlein A., Nuclear Medicines Oncology & Radiotherapy Institute, PK

Etoposide is a potent anticancer drug commonly used in a variety of malignancies. High protein binding, requirement of fairly high doses of drugs to achieve sustained plasma levels and hypersensitivty issues are related to its [...]