Lapotko D.O. – TechConnect Briefs

Plasmonic Nanobubbles as Tunable Theranostic Agents

Lukianova-Hleb E., Constantinou P., Danysh D.S. Wagner B., Drezek R.A., Hafner J.H., Farach-Carson M.C., Carson D.D., Farach-Carson M.C., Lapotko D.O., Rice University, US

Plasmonic nanobubbles (PNB) were developed to support a cell level theranostics as the multi-functional, tunable and selective cellular probes. PNB is a transient and tunable vapor nanobubble that is generated on demand around overheated plasmonic [...]

Plasmonic Nanobubbles for Intracellular Targeting and Gene Therapy

Lukianova-Hleb E., Wen J., Meteletsa L., Brenner M., Chang J., Lapotko D.O., Rice University, US

Intracellular molecular targeting (IMT) and gene transfection of eukaryotic cells is widely used for research and for developing gene cell therapy. However, the existing IMT methods lack selectivity, efficacy and safety when heterogeneous cell systems [...]

Plasmon nanoparticle-generated photothermal bubbles as universal biomedical agents

Hleb E.Y., Yakush N.A., Hafner J.H., Drezek R.A., McNew J.A., Lapotko D.O., A. V. Lykov Heat & Mass Transfer Institute, BY

We report the concept and preliminary experimental evaluation of the new optical methods and agent, whose properties provide tunable effect from non-invasive optical sensing to selective mechanical damage at nano-scale and in living tissues and [...]

Method of LANTCET for cancer diagnostics and treatment at cell level

Hleb E.Y., Zastinskaya I.A., Ilyukova I.I., Semenenya I.N., Hafner J.H., Hanna E.Y., Myers J.N., Zhdanok S.A., Lapotko D.O., A. V. Lykov Heat & Mass Transfer Institute, BY

We have developed the method of LANTCET (laser-activated nano-thermolysis as a cell elimination technology) for selective detection and destruction of individual tumor cells by generating intracellular photothermal bubbles around the clusters of gold nanoparticles. Bare [...]