To speed up the process of central nervous system (CNS) recovery after injury, the need for real-time measurement of axon regeneration in vivo is essential to assess the extent of injury, as well as the [...]
Skin is a highly stratified and impermeable tissue that confers specific size, charge, hydrophilic and lipophilic constraints on the types of molecules that can diffuse across it. Here we report the use of a novel [...]
, Boisgard R.
, Boisseau P.
, Coll J.L.
, Couffin A.C.
, Delmas T.
, Dufort S.
, Fraichard A.
, Gravier J.
, Heinrich E.
, Mérian J.
, Navarro F.
, Tavitian B.
, Texier I.
, Thomann J.S.
, CEA-Grenoble, FR
A new technology for the encapsulation of lipophilic molecules -both drugs and contrast agents dedicated to chemotherapy, phototherapy, or fluorescence imaging in oncology- has been developed, based on oil-in-water nanoemulsions. Thorough physico-chemical characterizations of the [...]
To study the mechanical response of both in vivo and in vitro neurons, we have developed a novel platform for in-situ high-resolution live-imaging of cells and tissues under applied mechanical strain. The system is capable [...]
We have systematically examined the effects of chitosan film or chitosan in combination with nanometal particles (nanogold or nanosilver particles) on the growth of Schwann cells (S16) and DRG neurons (50 B 11). Results of [...]
We utilized quantum dots (QD) as a unique nanoscaffold with uniform size and well-defined structure to assemble membrane immune receptors on the surface of the dots at desired density. Such QD/receptor biosensors appear to be [...]
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted diseases (STDs) in the USA, and therefore, of major public health significance. C. trachomatis invades the mucosal surface of the female genital tract consequently triggering [...]
In this abstract, we demonstrate that cerium oxide nanoparticles protect against neurodegeneration in a mouse model of Parkinson’s Disease.
Recently, we and others have developed several cell models for the investigation of the molecular mechanisms underlying the cytotoxicity of nanoparticles of several metallic and non-metallic oxides. These important findings have raised the awareness for [...]
In this work, two formulations kinds of diblock copolymers ((poly(2- methacryloyloxy)ethyl phosphorylcholine)-co-poly(2-(diisopropylamino)ethyl methacrylate(PMPC25-‐PDPA70) and poly(ethylene glycol)-co-poly(2- (diisopropylamino)ethyl methacrylate)(PEO113-‐PDPA70))will be employed,blending them in series ratios in order to obtain the best morphology and size across the [...]
In the present work we report the dopamine (DA) molecules stabilization in the network of nanostructured silica materials with the objective of using these as reservoirs of DA release in the brain. For this purpose [...]
Silent brain infarcts are often asymptomatic, but these micro-lesions can cause considerable neurodegenerative damage if they remain undetected and untreated. Cells undergo rapid irreversible necrosis at the ischemic core; however, viable cells in the penumbra [...]
Chronic inflammation plays a pivotal role in promoting disease pathology in the central nervous system (CNS). Microglial cells are the main innate immune effector cells in the CNS and orchestrate these neuroinflammatory reactions that ultimately [...]
This study was to investigate the effects of Mitomycin C on the scleral collagen surfaces by atomic force microscopy (AFM). Two non-contact mode AFM machines were used to observe changes in the morphological characteristics of [...]
It is well-known that the frictional force between the archwire (AW) and the bracket reduces the efficiency of orthodontic treatment. It is affected not only by geometry of self-ligating brackets but also by physical changes [...]
The trend of nanoscaling brings engineering down to the dimensions of molecular structures but in so doing poses also the problem of how to create the reliable system from the molecular components which experience permanent [...]
In Ukraine the first medical nanotechnology drugs were synthesized and patented in 1998 (http://www.nanolab.com.ua). These are such drugs as intracorporeal biocorrector (ICBB), magnet-controlled sorbent (MCS-B) and Micromage-B (Belousov A.N., 1997, 1998, 2000). Basis of the [...]
Gold nanoparticles (GNPs) are widely used in biological and clinical applications due to their favorable optical and chemical properties. The scientific understanding of the intracellular uptake of GNP is required for biomedical applications, such as [...]
The Zona Pellucida (ZP) is an extracellular membrane surrounding mammalian oocytes. The so called “zona hardening” has a key role in the fertilization process as it produces a block of polyspermy also through an increase [...]
Novel multistranded and alternative DNA, RNA and plasmid microarrays have been developed that allow for immobilization of intact, nondenatured nucleic acids. Biomolecules are anchored onto a solid support and can move freely, while researchers experiment [...]
We study the feasibility of analysis and the evaluation of large-scale genomic and proteomic data by applying frequency concepts. The frequency-domain estimates and measures lead to the informative analysis departing from statistical methods. The frequency [...]
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 13, 2011
Industry sector: Medical & Biotech