Cancer Nanotechnology – TechConnect Briefs

New High Conductance DEP Devices for Detection of Cancer Related DNA Nanoparticulate Biomarkers and Nanoparticles in Whole Blood

Heller M.J., Sonnenberg A., University of California San Diego, US

The ability to rapidly detect cell free circulating (cfc) DNA nanoparticulate biomarkers, drug delivery nanoparticles and virus directly from blood is a major challenge for nanomedicine. We have now developed unique, simple and practical high [...]

Label-free Raman Micro-Spectral Imaging of the Microenvironment of PANC-1 Spheroids

Chernenko T., Shah R., Zuser E., Diem M., Amiji M., Northeastern University, US

Spheroids are 3D tumor models, which reflect diverse properties of the growing tumor. Due to its avascular microenvironment, initial tumor growth patterns as well as subsequent tumor-core biochemistry may be studied in depth, from which [...]

Plasmonic Nanobubbles as Tunable Theranostic Agents

Lukianova-Hleb E., Constantinou P., Danysh D.S. Wagner B., Drezek R.A., Hafner J.H., Farach-Carson M.C., Carson D.D., Farach-Carson M.C., Lapotko D.O., Rice University, US

Plasmonic nanobubbles (PNB) were developed to support a cell level theranostics as the multi-functional, tunable and selective cellular probes. PNB is a transient and tunable vapor nanobubble that is generated on demand around overheated plasmonic [...]

Polymersomes and Imaging: A Quantitative Approach

Joseph A.S., Brown N.J., Battaglia G., University of Sheffield, UK

Nano-sized carriers are widely used as imaging tools. Quantification of the amount of carrier delivered provides useful informations in development and testing stages. This work describes a HPLC method to quantify fluorescent labelled polymersomes. Polymersomes [...]

Investigating the role of the FOXA1 protein in cancer with Scanning Probe Microscopy

Theodorou I., Imperial College London, UK

The FOXA1 protein has generated considerable interest for its use as a biomarker in breast cancer. In this project, the binding kinetics of FOXA1 with the BRCA1 and FOXC2 are investigated using Scanning Probe Microscopy. [...]

Enhanced Cell Electro-permeabilisation Combined with Phototherapy to Target-Killing Cancer Cells by Using Multi Functional Carbon Nanotubes

Lee P-C, National Taiwan University, TW

Carbon nanotubes (CNTs) have been proposed and actively explored as multifunctional innovative carriers for drug delivery. This project presents a new modality for cell electro-permeabilisation based on the use of CNTs and external static electric [...]

Polymer-based delivery vehicle for cisplatin

Vieira D.B., Menck C.F.M., Carmona-Ribeiro A.M., University of Sao Paulo, BR

Cisplatin (CisPt) is one of the most widely used agents to treat a variety of tumors, but dose-limiting toxicities or intrinsic and acquired resistance limit its application. We report a unique strategy to deliver cisplatin [...]

Prostate Cancer-Specific Drug Delivery and Imaging System: Design, Synthesis, and Characterization of Multi-functional AuNPs

Dao K-L, Northeastern University, US

A multifunctional gold nanoparticulate (mfAuNPs) drug delivery system that is specific for prostate cancer therapy will be presented. A synthetic modular approach is established to prepare-a)a prostate specific membrane antigen (PSMA) ligands for targeting the [...]

The Effect of Anticancer Nanotherapy on Lewis Lung Carcinoma

Orel V.E., Shevchenko A.D., Nikolov N.A., Dzyatkovskya N.N., Romanov A.V., Richalskiy A.Yu., Burlaka A.P., Lukin S.M., Uvarov V.N., Schepotin I.B., National Cancer Institute, UA

Introduction. Current forms of antitumor anthracycline antibiotic doxorubicin (DOXO) are highly toxic to the patient and can cause systematic complications, most notably cardiotoxicity. Systemic toxicity can seriously decrease the effectiveness of the drug since a [...]

Overcome the Doxorubicin Resistance by Multimodal Nanoparticles in Mice

Lai P.S., Hsu C.Y., Lu H.-L., Yu H.-P., Syu W.-J., Shieh M.J., National Chung Hsing University, TW

The efficacy of many chemotherapeutic agents is reduced in cells that have developed multiple drug resistance (MDR). To address this important problem, a biodegradable polymer was coupled to the photosensitizer and the resulting photosensitizer-nanoparticles were [...]

Effects of Caffeic Acid Incorporated into Solid Lipid Nanoparticles in Cancer Cells

Kutlu H.M., Guney G., Iscan A., Genc L., Anadolu University, TR

Nanotechnology has great potential to make an important role in prevention of cancer, detection, diagnosis, imaging and treatment. Nanoparticles are at the cutting edge of the rapidly developing area of nanotechnology. Solid lipid nanoparticles (SLNs) [...]

Importance of Solid Lipid Nanoparticles in Cancer Therapy

Guney G., Kutlu H.M., Anadolu University, TR

A drug delivery system can be defined as a system that capable of releasing a carried bioactive agents in a specific location within the body at a specific rate. Anti- cancer drugs can be associated [...]

Folate-Conjugated Gold Nanoparticles for Cancer Nanotechnology Applications

Brandenburg K.S., Shakeri-Zadeh A., Mansoori G.A., University of Illinois at Chicago, US

A need exists to target cancer treatments specifically to the tumor site, without damaging healthy tissue. This need can be achieved through the proper application of nanotechnology, namely gold nanoparticles conjugated to Folate. Folate is [...]

Investigation of Taxol effects on morphological and micromechanical properties of human endometrial adenocarcinoma cells by AFM

Kim J.H., Kim K.S., Cho C.H., Choi Y.J., Kim J.H., Kim K.S., Choi Y.J., Jung G.B., Jung M-H, Yoon K-S, Woo Lee J., Lee G.J., Jung G.B., Jung M-H, Park H.K., Kyung Hee University, KR

The effects of Taxol on morphological and micromechanical properties of human endometrial adenocarcinoma (Ishikawa cell), were investigated by atomic force microscopy (AFM). The morphological and mechanical properties of the Ishikawa cell were significantly changed by [...]

In-vitro testing of realgar nanoparticles for treatment of multiple myeloma cells

Balaz P., Sedlak J., Pastorek M., Cholujova D., Bujnakova Z., Institute of Geotechnics, Slovak Academy of Sciences, SK

Realgar As4S4 has been used in traditional Chinese medicine externally or even orally to treat psoriasis,syphilis and malaria.However,its broader healing effect was documented recently.The possibility to synthesize realgar particles as nanosuspensions brings new therapeutic strategies [...]

Sulfur-33 Nanoparticles: A Possible Target for Neutron Capture Therapy of Cancer

Porras I., University of Granada, ES

Sulfur nanoparticles, enriched in the isotope S-33 are potential neutron capturers for enhancing neutron radiation dose in tumors, because of a nuclear reaction of this isotope which produces a high energy alpha particle which delivers [...]

Cytotoxic studies of PEG functionalized ZnO Nanoparticles on MCF-7 cancer cells

Rodriguez Martinez C., Ramirez Vick J.E., Perales O., Singh S.P., University of Puerto Rico-Mayagüez, US

Nanoparticles have shown great promise in biomedical applications. Zinc oxide (ZnO) nanoparticles are being explored for various applications such as sun screen lotion, antimicrobial properties, advanced textiles, photodynamic therapy and electronic devices. We have synthesized [...]

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