The ability to rapidly detect cell free circulating (cfc) DNA nanoparticulate biomarkers, drug delivery nanoparticles and virus directly from blood is a major challenge for nanomedicine. We have now developed unique, simple and practical high [...]
Spheroids are 3D tumor models, which reflect diverse properties of the growing tumor. Due to its avascular microenvironment, initial tumor growth patterns as well as subsequent tumor-core biochemistry may be studied in depth, from which [...]
Plasmonic nanobubbles (PNB) were developed to support a cell level theranostics as the multi-functional, tunable and selective cellular probes. PNB is a transient and tunable vapor nanobubble that is generated on demand around overheated plasmonic [...]
Nano-sized carriers are widely used as imaging tools. Quantification of the amount of carrier delivered provides useful informations in development and testing stages. This work describes a HPLC method to quantify fluorescent labelled polymersomes. Polymersomes [...]
The FOXA1 protein has generated considerable interest for its use as a biomarker in breast cancer. In this project, the binding kinetics of FOXA1 with the BRCA1 and FOXC2 are investigated using Scanning Probe Microscopy. [...]
Carbon nanotubes (CNTs) have been proposed and actively explored as multifunctional innovative carriers for drug delivery. This project presents a new modality for cell electro-permeabilisation based on the use of CNTs and external static electric [...]
Cisplatin (CisPt) is one of the most widely used agents to treat a variety of tumors, but dose-limiting toxicities or intrinsic and acquired resistance limit its application. We report a unique strategy to deliver cisplatin [...]
A multifunctional gold nanoparticulate (mfAuNPs) drug delivery system that is specific for prostate cancer therapy will be presented. A synthetic modular approach is established to prepare-a)a prostate specific membrane antigen (PSMA) ligands for targeting the [...]
, Dzyatkovskya N.N.
, Lukin S.M.
, Nikolov N.A.
, Orel V.E.
, Richalskiy A.Yu.
, Romanov A.V.
, Schepotin I.B.
, Shevchenko A.D.
, Uvarov V.N.
, National Cancer Institute, UA
Introduction. Current forms of antitumor anthracycline antibiotic doxorubicin (DOXO) are highly toxic to the patient and can cause systematic complications, most notably cardiotoxicity. Systemic toxicity can seriously decrease the effectiveness of the drug since a [...]
The efficacy of many chemotherapeutic agents is reduced in cells that have developed multiple drug resistance (MDR). To address this important problem, a biodegradable polymer was coupled to the photosensitizer and the resulting photosensitizer-nanoparticles were [...]
Nanotechnology has great potential to make an important role in prevention of cancer, detection, diagnosis, imaging and treatment. Nanoparticles are at the cutting edge of the rapidly developing area of nanotechnology. Solid lipid nanoparticles (SLNs) [...]
A drug delivery system can be defined as a system that capable of releasing a carried bioactive agents in a specific location within the body at a specific rate. Anti- cancer drugs can be associated [...]
A need exists to target cancer treatments specifically to the tumor site, without damaging healthy tissue. This need can be achieved through the proper application of nanotechnology, namely gold nanoparticles conjugated to Folate. Folate is [...]
, Choi Y.J.
, Jung G.B.
, Jung M-H
, Kim J.H.
, Kim K.S.
, Lee G.J.
, Park H.K.
, Woo Lee J.
, Yoon K-S
, Kyung Hee University, KR
The effects of Taxol on morphological and micromechanical properties of human endometrial adenocarcinoma (Ishikawa cell), were investigated by atomic force microscopy (AFM). The morphological and mechanical properties of the Ishikawa cell were significantly changed by [...]
Realgar As4S4 has been used in traditional Chinese medicine externally or even orally to treat psoriasis,syphilis and malaria.However,its broader healing effect was documented recently.The possibility to synthesize realgar particles as nanosuspensions brings new therapeutic strategies [...]
Sulfur nanoparticles, enriched in the isotope S-33 are potential neutron capturers for enhancing neutron radiation dose in tumors, because of a nuclear reaction of this isotope which produces a high energy alpha particle which delivers [...]
Nanoparticles have shown great promise in biomedical applications. Zinc oxide (ZnO) nanoparticles are being explored for various applications such as sun screen lotion, antimicrobial properties, advanced textiles, photodynamic therapy and electronic devices. We have synthesized [...]
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 13, 2011
Industry sector: Medical & Biotech
Topicss: Biomaterials, Cancer Nanotechnology