Papers:
Fabrication of 1D nanochannels with thin glass wafers for single molecule studies
Hoang H., Segers-Nolten I., Tas N., de Boer M., Subramaniam V., Elwenspoek M., Mesa+ Institute for Nanotechnology, NL
1D nanochannels are fabricated by direct bonding between the silicon wafer containing the nanochannels, microchannels, access holes and the blank thin glass of 170 µm thickness. The thin glass wafers are used as channel covers [...]
Nanodroplet Impact on Liquid Substrates via Molecular Dynamics
In this paper, several aspects of the dynamic behaviour of liquid nanodroplets impacting on liquid substrates are investigated using molecular dynamics (MD) simulations. We consider liquid droplets of 5-10 nm in diameter, consisting of 7,000 [...]
Embeddable Low-Voltage Micropump using Electroosmosis of the Second Kind
A low-voltage micropump with no moving parts and based on standard MEMS fabrication techniques has been developed. High pumping rate is achieved by using electroosmosis of the second kind (EO2). The pump has been characterized [...]
Novel piezo motor enables positive displacement microfluidic pump
Microfluidic pumping mechanisms, such as membrane micro pumps, create a pulsed stream with generally low pressure, low flow and limited precision. We present a novel piezoelectric motor that is used to create a positive displacement [...]
Chaotic advection induced by a magnetic chain in a rotating magnetic field
Kang T.G., Hulsen M.A., Anderson P.D., den Toonder J.M.J, Meijer H.E.H., Eindhoven University of Technology, NL
We investigated chaotic advection induced by a magnetic chain suspended in a fluid in a rotating magnetic field. Our main focus is on the dynamics of the chain and the route to induce chaotic mixing, [...]
Separation dynamics of binary liquid mixtures – Theory & Experiment
We study how chemically patterned surfaces can be applied for the separation of two incompatible liquids and introduce a novel simplified separation scheme utilizing surfaces with an abrupt change of surface energy. Firstly we analyse [...]
Dynamics and distribution of counterions in the vicinity of a flexible polyelectrolyte
Transport properties of polyelectrolytes in solution, such as electrophoretic mobilities, are strongly related to the distribution of the counterions in the vicinity of the molecules. When the charge density of the polyelectrolyte is above a [...]
A Microfluidic Array with Micro Cell Sieves for Cell Cytotoxicity Screening
There is currently great interest in cell arrays for cell-based studies to improve experimental throughput. Microfluidics is an inherently scalable technology, offering an exciting new alternative to fabricate cell arrays for cell studies in a [...]
Development of Immunoassay Microfluidic Chip Using Serial-flow Method
Hsieh J., Yin H-L, Huang T-T, Huang Y-C, Hsu H-H, Lin Y-S, Huang T-T, Huang Y-C, Instrument Technology Research Center, TW
A serial-type microfluidic chip toward immunoassay-on-chip is reported. The presented chip contains no active microvalves and micropumps, rendering its low cost and disposability. Due to the serial flowing of fluids, minimal control effort is required. [...]
A method for the highly parallel analysis of gene expression of single cells
Presented is a method for carrying out rapid single cell gene expression analyses on a large number of cells in parallel. The entire analysis is carried out on a DNA microarray. We demonstrate single molecule [...]
Automated Microfluidic Chip and System for the Synthesis of Radiopharmaceuticals on Human-Dose Scales
van Dam R.M., Elizarov A.M., Ball E., Shen C.K-F, Kolb H., Rolland J., Diener L., Williams D., Edgecombe B., Stephen T., Heath J.R., Siemens Molecular Imaging Biomarker Research, US
We present a fully-automated microfluidic system for the multi-step chemical synthesis of radiopharmaceuticals such as radiolabeled probes for positron emission tomography (PET). In earlier work, we developed a proof-of-principle PDMS microfluidic chip with a coin-shaped [...]
Microfluidic Cell Culture System for Live Cell Imaging
Nanopoint has developed a novel micro-fabricated live cell containment device called cellTRAYTM designed specifically for imaging live cells. The device enables the precise containment of cells in an optical glass substrate, the size of a [...]
Multifunctional Microvalves Control by Optical Illumination on Nanoheaters and its Application in Centrifugal Microfluidic Devices
Park J.M., Cho Y-K, Lee B-S, Lee J-G, Lee B-S, Lee J-G, Ko C., Samsung Advanced Institute of Technology, KR
We report ultrafast control of phase-change based microvalves utilizing nanoheaters; ferronanoparticles dispersed in paraffin wax, and heating by optical illumination using a 808 nm laser diode. High speed camera images showed that the actual response [...]
Methods of energizing micro flows by acoustic and electric fields
We present two different concepts for energizing (e.g. mixing, pumping) of micro flows, which rely on the coupling of acoustic and electromagnetic energy into a liquid. Both concepts are analyzed using computational fluid dynamics (CFD) [...]
Droplet-based Segregation and Extraction of Concentrated Samples
Buie C.R., Buckley P., Hamilton J., Ness K.D., Rose K.A., Lawrence Livermore National Laboratory, US
Incorporating microfluidic-based technologies into bio-analytical instruments has many benefits including reduced sample consumption, faster response times, and improved sensitivity. To achieve these benefits, microfluidic analysis often requires sample concentration and separation techniques, e.g., isotachophoresis or [...]
Liquid transport detection using single FET devices
Observation and monitoring liquid transport and transport in liquids is a major task for lab on a chip applications and research. We use novel thin film FET devices based on silicon-on-insulator (SOI) substrates as planar [...]
Numerical and Experimental Investigation of Three-Dimensional Hydrodynamic Focusing in Polydimethylsiloxane (PDMS) Microchannels
In this work, we have designed and fabricated a three-dimensional hydrodynamic focusing microfluidic device, as shown in Figure 1. The design of the device is modified from that of a previous study [1], which comprises [...]
Molecular Dynamics Simulations of Nano-Droplet Wetting on a Solid Surface
An initially spherical liquid droplet is located between two moving parallel surfaces (or walls). The shape of the droplet in contact with the solid surfaces is studied by applying continues pressure to the moving walls. [...]
Lithographic fabricated ultra hydrophobic and porous plant-like surfaces for bio chip applications
A novel method for fabricating ultra-hydrophobic surfaces for bio chip and MEMS applications is presented. The base of this method is a lithographic process with some substantial changes of the exposure conditions. Plant-like structures are [...]
A Microfluidic Mixer for Chaotic Mixing of Magnetic Particles
Magnetic isolation of specific biological entities through utilizing super-paramagnetic micro-particles has been of great interest in both bench-top and microfluidic platforms. Since the magnetic particles and target entities are suspended in separate fluids, prior to [...]
Enhancement of micro-flow mixing using DC nonlinear electrokinetic vortices
Electroosmotic flow (EOF) is a fundamental electrokinetic phenomenon which finds extensive use in wide varieties of practical biochip applications and analyses. Generally, the dielectric materials (PDMS, glass, etc.) used to construct microchips have low dielectric [...]
Quick “easy?!” determination of the diameter of nanocapillaries
Precise measurements of the inner diameter (ID) of nanocapillaries are of interest to many areas of study due to the high sensitivity of gas and liquid flows with respect to the radius of the capillary. [...]
Scaling Relation between Current through Suspensions of Carbon-doped TiO2 Nanoparticles in Silicone Oil and Reciprocal of Shear Rate under Combined Electric and Shear Fields
We synthesize carbon-doped TiO2 nanoparticles by hydrolysis of Tetra-n-butyl titanate Ti(OBu)4 in alcoholic solution. Ddodecylamine (DDA) works as template during synthesis. We accurately control carbon contents in nanoparticles by DDA content and carbonization temperature to [...]
A Microsystem and Model for Continuous Immunomagnetic Cell Sorting
We present a microsystem concept and mathematical model for the continuous sorting of magnetically labeled cells. The microsystem consists of two inlets, two partially connected microchannels, and two outlets. A soft-magnetic element is positioned beneath [...]
Simulation on biological cell transport in the microfluidic devices
We have developed a Bio-Particle (BP) simulation technique for the general particle movement in Lab-On-A-Chip devices. This has also been validated with experiments on biological cells (3T3 cell; diameter 10 μm). The cell motion under [...]
Three-Dimensional Transient Motion of Spherical and Deformable Droplet in L-Shaped Rectangular Microchannel
Three-dimensional transient motion of spherical and small deformable droplet in an L-shaped rectangular channel is investigated numerically. The methodology employed is front tracking coupled with the parallel adaptive refinement meshing code, referred as PARAMESH. The [...]
A Microfluidic Device for Opto-Electrochemical Sensing
To integrate functionality of transmembrane proteins to devices, a platform compatible with proteins and phospholipids membrane is required. In our effort to address the needs for current and future research, we report a microfluidic device [...]
Using epoxy resin to fabricate a master for microfluidic devices in poly(dimethylsiloxane)
This paper presents two methods for the production of UV epoxy resin masters for the replication of PDMS-based microfluidic chips. The epoxy resin master can be either fabricated by using a negative glass template which [...]
200um-class Polymeric Microneedle Fabricated by a Micro Injection Molding Technique
Extensive microneedle research has been conducted to enhance the efficiency of transdermal drug delivery. It has been expected and shown through experiments in vivo that microneedles can increase the skin permeability to deliver drugs by [...]
Control of Micro-Fluidic Flow using 3D Features
Lab-on-a-Chip sensors require precise control and mixing of samples, reagents and buffers. This paper will present new techniques for using Excimer Laser, micro-machined, three-dimensional (3D) channel and well features to pump and control fluids in [...]
Design & Fabrication of Ceramic Microarrays Using Powder Injection Molding
Microsystem technology has propelled the development of micro and multi-scale manufacturing techniques for more than a decade. Among these techniques, micro powder injection molding is drawing attention recently as one of the most cost-effective processes [...]
New sample injection methods for chip electrophoresis
Electrokinetic injection is commonly utilized in capillary chip electrophoresis (CE) even though mobility and matrix bias makes quantitation difficult. Hence, injection techniques that provide for both reproducible and precise injection of sample are warranted. Herein, [...]
Combining Additive and Substractive techniques in the design and fabrication of Microfluidic devices
Laminate construction of microfluidic devices offers a means to adopt both additive and subtractive manufacturing techniques for the development and manufacture of multiplexed fluidic devices that have porous membranes formed in-situ for applications in sample [...]
Magnetically Controlled Valve for Flow Manipulation in Polymeric Microfluidic Devices
Microfluidic devices (MDs) have emerged as novel analytical tools in many areas of science and industry. Their inherent qualities such as low power requirements, low sample consumption, rapid and parallel analysis, and automation provides unique [...]
Design, Fabrication & Testing of a Ceramic Microreactor for Nanoparticle Synthesis
Jain K., Wu C., Atre S., Kimura S., Jovanovic G., Sprenkle V., Canfield N., Narayanan V., Roy S., Oregon Nanoscience & Microtechnologies Institute, US
Nanoscale ceramic powders offer attractive prospects as building blocks for various high performance applications due to their excellent mechanical, thermal, dielectric and corrosion properties. Despite the availability of a plethora of nanoparticle synthesis processes the [...]
Micro and nano flow usage in future nuclear reactors
In nuclear reactors to mitigate the need for safety and the request for space of the fission products a new concept of micro-hetero nuclear fuel-structure has been developed. The new fuel design is based on [...]
On-site Screening of Avian Influenza Virus (AIV) by Polystyrene Microfluidic Chip Immunoassay
AIV Ag of A type with viral nucleoprotein (NP), which covers all AIV subtypes, including high-pathogenic AIV was determined by polystyrene microfluidic chip ELISA method. In micro-channels of chip instead of conventional 96-well microtiter plates, [...]
Pattern Characteristic by Electrostatic Drop-On-Demand Ink-jet Printing Using Capillary Inkjet Head System
Ink-jet printing technology is very attractive for forming micro-size patterns for flat panel displays (FPDS), semiconductor, biological and optical devices. Further the necessity of the industrial inkjet system has grown in the past years due [...]
Levitation of a Charged Microdroplet
A new method for levitation of a charged microdroplet is presented. The feedback-control consists of high-speed camera, flatness based follow-up controller and high-voltage amplifier.
Fabrication and Application in Microfluidics of Novel Transparent Preceramic Polymer Derived Glass Microcannels and Substrates
Generally, glass-based microfluidics with the chemical inertness and thermal stability have widely used, while plastics including PDMS have showed their convenience in fabricating microfluidic devices. Therefore, one can simply anticipate that it must be desirable [...]
A platform for assembly of electro-hydrodynamic microfluidics
Current approaches to build electro-hydrodynamic microfluidic devices involve the employment of standard photolithography methods in clean room environment [1] or/and the use of polymer-based manufacturing techniques [2]. Both of them require multiple steps to fabricate [...]
Filtration and emulsification with nanoengineered membranes
With microengineering techniques it is possible to manufacture very precise perforated membranes. The pores, which are well defined by photolithographic methods, allow accurate separation of particles by size. The membrane thickness is usually smaller than [...]
Microfluidic Valve-Controllable Magnetic Bead Receptacle: A Novel Platform for DNA Sequencing
In this paper, a novel and effective microfluidic platform for DNA Sequencing, particularly for sequencing-by-synthesis methods such as Pyrosequencing, based on valve-controllable PDMS channel system contains micrometer magnetic beads . Additionally, the proposed picoliter micofluidic [...]
Chaotic mixing using periodic and aperiodic sequences of mixing protocols in a micromixer
We conducted a numerical study on mixing in a barrier embedded micromixer with an emphasis on the effect of periodic and aperiodic sequences of mixing protocols on mixing performance. A mapping method was employed to [...]
Fixed-Valve Micropump Simulation and Optimization
Membrane pumps with fixed-geometry valves are ex- tremely simple to fabricate and have the potential to be highly reliable and cheap due to their simplicity. We have recently implemented a means of optimizing design parameters [...]
Particle Electrophoresis in Closed-both-end Capillary and Likely Charged Particle Aggregation Induced by AC Electric Field
Electroosmosis flow (EOF) is a critical issue in electrophoresis separation techniques. The magnitude of EOF problems and difficult level of its solution are demonstrated by 33 issued US Patents on different methods to suppress or [...]
Journal: TechConnect Briefs
Volume: 3, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 3
Published: May 20, 2007
Industry sector: Sensors, MEMS, Electronics
Topic: Micro & Bio Fluidics, Lab-on-Chip
ISBN: 1-4200-6184-4