Materials for Drug & Gene Delivery

Engineering of Recombinant Spider Silk Proteins Allows Defined Drug Uptake and Release

Scheibel T., Unibersity of BAyreuth, DE

Drug delivery systems allow tissue / cell specific targeting of drugs in order to reduce total drug amounts administered to an organism and potential side effects upon systemic drug delivery. Most drug delivery systems are [...]

Nitric oxide releasing PLGA microspheres for biomedical applications

Lautner G., Schwendeman S.P., Meyerhoff M.E., University of Michigan, US

In the current work, we encapsulated an S-nitroso species in biodegradable poly(lactic-co-glycolic acid (PLGA) microspheres (with diameter of 20-125 µm) that release nitric oxide (NO) for weeks in a continuous and controlled manner. The rate [...]

Electrospun nanofibers for Sustained Delivery of Cetylpyridinium Chloride for Buccal Topical Application

Zanin M.H.A., Santos V.A., Oliveira A.M., Cerize N.N.P., Borsatti M.A., Institute for Technological Research of the State of São Paulo - IPT, BR

The aim of this study was to prepare electrospun polymeric nanofiber mat composed of polyvinylpyrrolidone (PVP-Kollidon® 90F), ammonio methacrylate copolymer type B (PMMA-Eudragit® RS100) and cetylpyridinium chloride (CPC), 10:10:1 (wt/wt%) and its characterization for buccal [...]

HA-decorated nanoparticles as tumour-targeting nucleic acids carriers

Tirella A., Rios J.M., Tirelli N., University of Manchester, UK

The design of tools that allow for a targeted delivery of therapeutic cargos have a great potential in the treatment of many pathological conditions (e.g. cancer and autoimmune diseases). In the context of nucleic acids [...]

Efficient drug delivery for cancer treatment using amine-functional SiO2-LDH nanocomposites

Li L., Liu J., Gu W.Y., Gu Z., Gu W.Y., Gu Z., Liu J., Xu Z.P., Australian Institute for Bioengineering and Nanotechnology, AU

Target-specific delivery and sustained release of anticancer agents and siRNA has attracted considerable research interest in cancer chemotherapy. Recently, we have developed layered double hydroxide (LDH) vector to efficiently deliver drug and siRNA into the [...]

Thermally responsive lipid coated superparamagnetic nanoparticles for frequency triggered drug delivery

Patil-Sen Y., Eizadi Sharifabad M., Mercer T., Bond G., Patil-Sen Y., Sen T., University of Central Lancashire, UK

In this abstract, we report a series of novel thermally responsive lipid coated core-shell mesoporous silica-superparamagnetic iron oxide nanoparticles as drug delivery vehicles for potential use for cancer therapy under magnetic hyperthermia. Hydrophilic anticancer drug [...]

Nanomedicine in Neurodegenerative Disorders: understanding the journey

Tosi G., Ruozi B., Vilella A., Grabrucker A.M., Belletti D., Vandelli M.A., Boeckers T.M., Forni F., Zoli M., Sharma A., Sharma H.S., Muresanu D.F., Sharma A., Sharma H.S., Uppsala University, SE

The novelty of the last 3 years of research is on the fate of NPs made of poly-lactic-co-glycolic acid (PLGA) and engineered with g7, a glycopeptide that enhances BBB crossing capability, in the living mouse [...]

Nanodelivery of Cerebrolysin Induces Profound Neuroprotection in Heat Stroke Following Chronic Hypertension in Combination with SiO2 and Carbon Nanoparticles Induced Exacerbation of Brain Damage

Muresanu D.F., Sharma A., Sharma H.S., Patnaik R., Nozari A., Mössler H., Tian Z.R., Ozkizilcik A., Sharma A., Sharma H.S., Uppsala University, SE

Our military personals are often exposed to combat stress induced hypertension in an environment rich in various nanoparticles emanating from different sources e.g., gun powder explosion or blast injuries. Furthermore, combat or peacekeeping activity in [...]

TiO2 nanowired delivery of a Chinese traditional medicine DL-3-n-butylphthalide (DL-NBP) induces profound neuroprotection in concussive head injury

Feng L., Sharma A., Sharma H.S., Yin H., Lafuenta J.V., Ozkizilcik A., Tian Z.R., Sharma A., Sharma H.S., Bethune International Peace Hospital, CN

To develop suitable therapeutic strategies for concussive brain injury (CHI), we have explored the role of a Chinese traditional medicine DL-3-n-butylphthalide (DL-NBP) in a rat model. We delivered this compound alone and also using Titanium [...]

Mn nanoparticles exacerbates closed head injury induced blood-brain barrier disruption, brain pathology, and sensory motor dysfunctions. Neuroproetction by Nanowired delivery of 5-HT2 receptor antagonists Ketanserin and Ritanserin

Sharma A., Sharma H.S., Feng L., Muresanu D.F., Lafuente J.V., Tian Z.R., Ozkizilcik A., Smith M.A., Sharma A., Sharma H.S., Uppsala University, SE

This innovation deals with adverse effects of Mn nanoparticles on brain pathology in concussive head injury. Also Mn nanoparticles treatment alters therapeutic modalities. The novel data presented in the abstract show that Mn exposure to [...]

TiO2 Nanowired Cerebrolysin enhances neuroprotective effects of mesenchymal stem cells following concussive head injury at hot environments

Sharma A., Sharma H.S., Muresanu D.F., Feng L., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Concussive head injury (CHI) could lead to either instant death or lifetime disabilities. Our soldiers are highly vulnerable to CHI during combat operations. Thus, to treat these soldiers effectively novel strategies using combination therapy is [...]

Efficiency of different chitosan and its derivative nanoparticles for delivery of recombinant plasmid of Tibetan pig interleukin-7 gene and regulation effect in vivo on immune responses of mice

Wan X.P., Wang Z.Z., Yang X., Lang G., Sun W.K., Chen Y-H, Li J.L., Liu R., Gu Y.R., Liu R., Wang Z.Z., Lu X.B., Gao R., Sichuan University, CN

For sake of developing safe and effective technique to deliver and express animal immune gene in vivo to enhance comprehensive immunity of animal against infectious disease, the interleukin-7 gene of Tibetan pig was firstly cloned [...]

The use of Werner complexes as remarkably versatile bioconjugation reagents in the synthesis of redox repsonsive albumin nanoparticles containing camptothecin derivatives

Cavazos R.J., Morrison C.S., Lampe J.B., Nguyen D.T., Harris A.N., McFarlin B.K., Petros R.A., University of North Texas, US

Alfred Werner, the father of inorganic chemistry, received the Nobel Prize in 1913 for his pioneering work in formulating a theory to describe bonding patterns for coordination compounds. A number of complexes studied were amine [...]

Peptide RF482 Encapsulated Chitosan – PLGA Nanoparticles Inhibit Respiratory Syncytial Virus

Bawage S.S., Tiwari P.M., Dennis V.A., Singh S.R., Alabama State University, US

Worldwide, human respiratory syncytial virus (RSV) is one of the leading causes of lower respiratory tract infections in children and older adults. Currently, an anti-viral drug ribavirin and RSV neutralizing monoclonal antibody- palivizumab are the [...]

PLGA and PLGA-PEG nanoparticles loaded with curcumin and their effect on aflatoxin B1 in vitro

Rivero-Gonzalez A., Ramirez-Noguera P., Universidad Nacional Autonoma de Mexico, MX

The aim of this study was to evaluate the effect of nanoparticles prepared with polylactic-co-glycolic acid (PLGA) and PLGA with polyethylene glycol (PLGA-PEG) loaded with curcumin in human hepatocytes exposed to aflatoxin B1 in vitro. [...]

Schwann Cells and Dorsal Root Ganglion Neurons Are Differentially Susceptible to Oxidative Stress Induced by Silicon Dioxide Nanoparticles

Lai J.C.K., Jaiswal A.R., Idikuda V.K., Pfau J., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Silicon dioxide (SiO2) particles, including nanoparticles, have been increasing employed in diverse industrial and biomedical applications including those in drug formulations, food, and cosmetics as SiO2 has been generally regarded as a non-toxic substance. However, [...]

Co-Culturing Dorsal Root Ganglion Neurons with Schwann Cells Protects Them Against the Cytotoxic Effects of Silver Nanoparticles

Gao W., Leung S.W., Bhushan A., Lai J.C.K., Idaho State University College of Pharmacy, US

Because of their presumed inertness, silver nanoparticles are increasing employed in many consumer products. Nonetheless, their environmental and health hazard impact are not understood. Our previous studies led us to develop a co-culture model consisting [...]

A New and versatile method for preparing crystalline drug nanoparticle formulations

Higgins J.D., Merck Research Labs, US

The birth of the nanoparticle (nanos) drug delivery field arguably was seen over 20 years ago with the advent and application of simple oral crystalline nanoparticle formulations. This effective approach for enhancind oral absorption using [...]

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