Pfau J. – TechConnect Briefs

Schwann Cells and Dorsal Root Ganglion Neurons Are Differentially Susceptible to Oxidative Stress Induced by Silicon Dioxide Nanoparticles

Lai J.C.K., Jaiswal A.R., Idikuda V.K., Pfau J., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Silicon dioxide (SiO2) particles, including nanoparticles, have been increasing employed in diverse industrial and biomedical applications including those in drug formulations, food, and cosmetics as SiO2 has been generally regarded as a non-toxic substance. However, [...]

Zinc Oxide Nanoparticles Induced Apoptosis and Necrosis in Human Neuroblastoma and Astrocytoma Cells

Lai J.C.K., Lai M.B., Balaraju A.K., Neti A., Lai J.C.K., Lai M.B., Tadinada S.M., Idikuda V.K., Singh M.R.M., Mukka K., Pfau J., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Because of their escalating uses in industrial and biomedical applications, humans are increasing exposed to nanoparticles in occupational and other environmental settings. However, the environmental safety and health impact of such particles have not been [...]

Zinc Oxide Nanoparticles Induced Apoptosis and Necrosis in Hepatocellular Carcinoma HepG2 Cells

Tadinada S.M., Lai J.C.K., Lai M.B., Idikuda V.K., Mukka K., Singh M.R.M., Pfau J., Bhushan A., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy, US

Targeted drug delivery systems with minimal potential adverse/side effects are gaining utility in diverse applications. Uses of nanomaterials to design such targeted drug delivery are escalating exponentially. Nevertheless, the biocompatibility of nanomaterials is inadequately addressed. [...]

Effects of Silicon Dioxide Nanoparticles on Peripheral Nervous System Neural Cell Models

Jaiswal A.R., Lu S., Pfau J., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

Cell model systems in vitro facilitate the high through-put screening of putative toxicity of a variety of nanomaterials, including nanoparticles. However, most of such cell models consisted of non-neural cells. We have developed several central [...]