The analysis of cell free circulating (cfc) DNA and RNA nanoparticulate biomarkers continues to become more widely used for cancer diagnostics and management. Generally, cfc-DNA for “liquid biopsies” is isolated form plasma using relatively long [...]
The multi-kinase inhibitor sorafenib (tradename Nexavar®, Bayer) has been recently approved by the FDA for the treatment of non-resectable hepatocarcinoma and advanced renal carcinoma. Despite its proven survival benefit, sorafenib can lead to important side [...]
, Kreuziger A.-M.
, Mattoussi H.
, Merkl J.-P.
, Muroski M.
, Ostermann J.
, Safi M.
, Schmidtke C.
, Strouse G.
, Tran H.
, Weller H.
, University of Hamburg, DE
Glyconanomaterials are of great interest for bio-imaging to understand biological processes, for instance metabolism, cell-cell or virus-cell interactions, gluconeogenesis, and cancer. Herein, we present a strategy for the biofunctionalization of fluorescent quantum dots (QDs) from [...]
Dysregulation of the metabolic pathways of the sphingolipid ceramide has been shown to play key roles in cancer cell proliferation and survival. Targeting these pathways with exogenous modulators of ceramide metabolism such as the short [...]
CD44 is the major cell surface receptor of hyaluronic acid (HA) and mediates the response of cells to their cellular microenvironment. Whereas the standard isoform (CD44s) is ubiquitously expressed throughout the body, variant isoforms (CD44v) [...]
Lung cancer is the deadliest solid tumour among all types of cancer. Despite advances in surgery and drug discovery lung cancer remains difficult to treat. This is a result of unavoidable exposure to carcinogens, poor [...]
The objective of this study was to investigate an effect of conjugating folic acid (FOL) as a targeting ligand and conjugating methotrexate (MTX) as an anticancer drug on the formation of targeted nanoparticles. Beginning with [...]
Photodynamic therapy (PDT) is an emerging minimally invasive therapeutic modality for a variety of oncologic diseases. In recognition of their superior optical and surface plasmonic properties, gold nanoparticles (Au NPs) can be utilized as the [...]
Poly (styrene-alt-maleic anhydride), PSMA, is an amphiphilic alternating copolymer presenting a pH responsible self-assembly into nanotubes in aqueous solution. Its self-assembled structure with a 2nm hydrophobic inner diameter is stable in neutral pH solution, but [...]
Currently, only optimal surgical resection of all disease sites can improve survival of ovarian cancer patients. Even with the best microsurgical techniques, however, palpation and visual inspection for malignant tissue identification can result in microscopic [...]
Using NEBL proprietary “SNAP based Genes Expression” in conjuction with our proprietary “Submicron Arrays” (Anodic Porous Allumina and/or Kapton based Nanopores) , we use proprietary DNASER and Label Free Nanotechnologies to carry out : 1_Construction [...]
Oral Lichen Planus (OLP) is a common chronic inflammatory disease, which involves the mucous membranes of the oral cavity, with an overall age-standardized prevalence of 1.27% (0.96% in men and 1.57% in women) as reported [...]
Journal: TechConnect Briefs
Volume: 3, Biotech, Biomaterials and Biomedical: TechConnect Briefs 2015
Published: June 14, 2015
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Biomaterials, Cancer Nanotechnology