Cancer Nanotechnology – TechConnect Briefs

Dielectrophoretic Isolation and Detection of Cancer Related DNA and RNA Nanoparticulate Biomarkers from Blood and Plasma

Heller M.J., Marciniak J., Skowronski E., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA and RNA nanoparticulate biomarkers continues to become more widely used for cancer diagnostics and management. Generally, cfc-DNA for “liquid biopsies” is isolated form plasma using relatively long [...]

Targeted delivery of anti-cancer drug sorafenib through magnetic solid lipid nanoparticles

Grillone A., Redolfi Riva E., Moscato S., Sacco R., Mattoli V., Ciofani G., Italian Institute of Technology, IT

The multi-kinase inhibitor sorafenib (tradename Nexavar®, Bayer) has been recently approved by the FDA for the treatment of non-resectable hepatocarcinoma and advanced renal carcinoma. Despite its proven survival benefit, sorafenib can lead to important side [...]

Uptake Behavior of Glycoconjugated and Micellar-Encapsulated Quantum Dots on HeLa Cervical Cancer Cells

Merkl J.-P., Schmidtke C., Safi M., Muroski M., Alpers D., Tran H., Ostermann J., Kreuziger A.-M., Strouse G., Mattoussi H., Weller H., University of Hamburg, DE

Glyconanomaterials are of great interest for bio-imaging to understand biological processes, for instance metabolism, cell-cell or virus-cell interactions, gluconeogenesis, and cancer. Herein, we present a strategy for the biofunctionalization of fluorescent quantum dots (QDs) from [...]

Oxidized Graphene Nanoribbons as a Delivery System for the Bioactive Sphingolipid Ceramide

Suhrland C., Truman J.P., Sitharaman B., Stony Brook University, US

Dysregulation of the metabolic pathways of the sphingolipid ceramide has been shown to play key roles in cancer cell proliferation and survival. Targeting these pathways with exogenous modulators of ceramide metabolism such as the short [...]

Characterisation of THP-1 macrophages as an in vitro model for CD44-targeted therapies

M. Rios de la Rosa J., Tirella A., Gennari A., Tirelli N., University of Manchester, UK

CD44 is the major cell surface receptor of hyaluronic acid (HA) and mediates the response of cells to their cellular microenvironment. Whereas the standard isoform (CD44s) is ubiquitously expressed throughout the body, variant isoforms (CD44v) [...]

Inhalable Stimuli-Responsive Theranostic Nanoparticles for Cancer in Deep Lung Tissue

Abbas Y.H., American University in Cairo, EG

Lung cancer is the deadliest solid tumour among all types of cancer. Despite advances in surgery and drug discovery lung cancer remains difficult to treat. This is a result of unavoidable exposure to carcinogens, poor [...]

Influence of conjugating folic acid and methotrexate on physicochemical properties of P(CL)-mPEG nanoparticles

Issarachot O., Mahidol University, TH

The objective of this study was to investigate an effect of conjugating folic acid (FOL) as a targeting ligand and conjugating methotrexate (MTX) as an anticancer drug on the formation of targeted nanoparticles. Beginning with [...]

Mitochondria-targeting Gold Nanoparticles for Improved Therapeutic Efficacy of Photodynamic Therapy of Breast Cancer

Yang Y., Gao N., Hu Y., Jia C., Du H., Wang H., Stevens Institute of Technology, US

Photodynamic therapy (PDT) is an emerging minimally invasive therapeutic modality for a variety of oncologic diseases. In recognition of their superior optical and surface plasmonic properties, gold nanoparticles (Au NPs) can be utilized as the [...]

Synthesis of a pH Responsive Polymeric Drug Delivery – tailoring functionalization for effective delivery

Li X., Malardier-Jugroot C., Royal Military College of Canada, CA

Poly (styrene-alt-maleic anhydride), PSMA, is an amphiphilic alternating copolymer presenting a pH responsible self-assembly into nanotubes in aqueous solution. Its self-assembled structure with a 2nm hydrophobic inner diameter is stable in neutral pH solution, but [...]

A Multifunctional Theranostic Nanoplatform for Image-Guided Surgery and Intraoperative Therapy

Taratula O., Schumann C., Duong T., Taylor K.L., Taratula O., Oregon State University, US

Currently, only optimal surgical resection of all disease sites can improve survival of ovarian cancer patients. Even with the best microsurgical techniques, however, palpation and visual inspection for malignant tissue identification can result in microscopic [...]

Microarray based Functional Nanoproteomics and Cancer

Nicolini C., Peshkova E., Fondazione ELBA Nicolini, US

Using NEBL proprietary “SNAP based Genes Expression” in conjuction with our proprietary “Submicron Arrays” (Anodic Porous Allumina and/or Kapton based Nanopores) , we use proprietary DNASER and Label Free Nanotechnologies to carry out : 1_Construction [...]

From Nanogenomics and Structural-Functional Proteomics to Personalized Medicine for Oral Lichen Planus (OLP) as a Translational Model of Oral Cancer Usefull to Introduce an Industrial Technical Innovation

Nicolini C., Peshkova E., Bragazzi N., Fondazione ELBA Nicolini, US

Oral Lichen Planus (OLP) is a common chronic inflammatory disease, which involves the mucous membranes of the oral cavity, with an overall age-standardized prevalence of 1.27% (0.96% in men and 1.57% in women) as reported [...]

Papers: