Papers:
A Nanopore Biomimetic Device Quantitatively Detects Early Stage Cancer Cells; a Contour Map Multiple Variable Correlation Method Assesses the Heat of Cancer Cells Released
Chen E.T., Shen J. Thornton Y., Ngatchou C., Duh S-H, Kissinger P.T., Advanced Biomimetic Sensors, Inc., US
Detecting low abundance cancer cell is challenged by the complex instrumentation and time consuming assays. We report a unique cancer cell detection device that is capable of detecting low abundance MDA-MB-231 breast cancer cells based [...]
EGF conjugated gold and silver nanoparticles for imaging EGFR over-expressing cells
Purpose: To create and validate a novel SERS-based nanoprobe for optical imaging of the epidermal growth factor receptor (EGFR). Experimental Design: Gold and silver nanoparticles (Au/AgNPs) were synthesized and coupled to epidermal growth factor (EGF) [...]
Immunodiagnosis for cervical cancer using antibody-gold nanoparticle conjugate
Tapaneeyakorn S., Thepthai C., Apiwat N., Dharakul T., National Science and Technology Development Agency, TH
Cervical cancer is a leading cause of cancer deaths among women. It is most often caused by persistent infections with high-risk human papillomavirus (HPV). Since current screening programs are either complex or costly to run, [...]
Polymalic acid-based nanodrugs: Anti-tumor efficacy and host compatibility
Holler E., Ding Hui, Patil R., Portilla J., Inoue S., Gangulum P., McNeil S.E., Patri A., Dobrovolskaia M.A., Black K.L., Ljubimova J.Y., Cedars-Sinai Medical Center, US
A polyanionic drug carriers is presented that penetrates biobarriers and targets molecular cancer markers of human breast and brain cancer. The carrier platform is poly(beta-L-malic acid) (PMLA), which is highly water soluble and biodegradable to [...]
Combined targeted hyperthermia and drug delivery with magnetic nanoparticles
Cancer remains the second leading cause of deaths worldwide and in the U.S. alone every year there are over 1.5 million new diagnoses. Technologies that would allow targeted destruction of tumours by localising the delivery [...]
VEGF-dependent mechanism of anti-angiogenic action of diamond nanoparticles in glioblastoma multiforme tumor
Grodzik M., Sawosz E., Wierzbicki M., Hotowy A., Prasek M., Jaworski S., Chwalibog A., Warsaw University of Life Sciences, PL
Inhibition of tumor angiogenesis suppresses tumor growth and prevents metastasis, and is a key target in cancer therapy. Novel materials, nanoparticles of carbon allotropes (C60 fullerenes, graphite nanoparticles, multi-walled carbon nanotubes, single-walled carbon nanotubes and [...]
Electrospun 5-fluorouracil loaded bovine serum albumin-polyvinylpyrrolidone nanofibers
5-FU loaded bovine serum albumin (BSA)/ polyvinylpyrrolidone (PVP) nanofibers prepared using an electrospinning process. The nanofibers were characterised by scanning electron microscopy (SEM) energy - dispersion spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction [...]
Mn-Zn Ferrite and Photosensitizer Co-Loaded Cancer Theranostic Agent for Magnetic Resonance Imaging and Photodynamic Therapy
Developing a nanodevice with simultaneous cancer imaging and therapy is one of the promising approaches for cancer treatments. In this report, a multifunctional cancer theranostic system based on magnetic resonance (MR) contrast agent and photosensitizer [...]
Copper complexes loaded on nanostructured TiO2 materials as citotoxic agents of cancer cells
In the present work ammonium tetrachlorocuprate (II) and copper (II) chloride were loaded on nanostructured mesoporous titania for determinate their anticancer properties. Copper-TiO2 materials were prepared using the sol-gel technology. Characterization of Copper complexes and [...]
Supermagnatic Iron Oxide Nanoparticles Toxicity to Mammalian Cells
The present study investigates the development of superparamagnetic iron oxide nanoparticles as a controlled release drug formulation and use as anticancer therapeutic agents. Iron oxide nanoparticles (IONPs) were synthesized using ultrasonic irradiation of iron pentacarbonyl [...]
Targeted Cancer Therapy by Immunoconjugated Gold-Gold Sulfide Nanoparticles Using Protein-G as a Cofactor
Gold-gold sulfide nanoparticle (GGS-NP) with controllable near infrared (nIR) absorption was synthesized from a simple reaction of chloroauric acid and sodium thiosulfate. Through PEGylated recombinant Protein-G (ProG), ProG-conjugated GGS-NPs for antibody capture by Fc domain [...]
Smaller sizes of Ag-PVP Nanoparticles Control Inflammatory Responses, and Reduce CD80 and CD86 Expression Levels, in Macrophages Infected with Chlamydia trachomatis
Chlamydia trachomatis is an important cause of sexually transmitted infection that can manifest itself as either acute cervicitis, pelvic inflammatory disease, and more commonly as a chronic asymptomatic infection. Early intervention strategies that can reduce [...]
Cardiomyocyte Function on Poly-Lactic-co-Glycolic Acid: Carbon Nanofiber Composites under Electrical Stimulation
In recent research, it was demonstrated that the use of nano-materials can promote the growth of cardiomyocytes when compared to the use of conventional or micro-structured materials. One such nano-material consisted of poly-lactic-co-glycolic acid (PLGA) [...]
Ultrastructural and mechanical effects of collagen cross-linking treatment on human corneo-scleral tissues
The aim of this study was to quantitatively examine the immediate effects of a photooxidative collagen cross-linking treatment with photosensitizer riboflavin and 370 nm UVA light in in vitro rabbit dermal collagen fibrils. These effects [...]
Functionalized Self-Assembling Peptides for Immediate Hemostasis and Accelerative Liver Tissue Regeneration
Cheng T.Y., Wu H.C., Chang W.H., Huang M.Y., Lee C.H., Wang T.-W., Department of Materials Science and Engineering, National Tsing Hua University, TW
Traumatic injury or surgery may trigger extensive bleeding. However, conventional hemostatic methods have limited efficacy and may cause surrounding tissue damage. In this study, we use self-assembling peptides (SAPs) and specifically extend fragments of functional [...]
Ultrastructure of hepatic cells in rabbits after injection of nanoparticles MCS-B
In order to determine ultrastructural reconstructions in hepatic cells under effect of nanoparticles of magnetite (MCS-B), an experiment was conducted on 45 rabbits. Ultrastructural changes in hepatocyte organelles manifested pronounced signs of activation of reparative [...]
Molecular Changes in Rat Brain Due to Air Nano Pollution
Ljubimova J.Y., Gangalum P.R., Portilla-Arias J., Patil R., Konda B., Paff M., Markman J., Inoue S., Espinoza A., Chesnokova A., Kleinman M., Holler E., Black K.L., Cedars-Sinai Medical Center, US
Air pollution has been found to cause neurodegeneration, deposition of heavy metals & beta amyloid plaques in the brain. Air pollution constitutes of nanopollutant of different sizes that can enter the system and cause diseases. [...]
Ceria Nanopartciles Reduce Disease Severity in a Mouse Model of Multiple Sclerosis
Multiple sclerosis affects 300,00 people in the United States alone with 400 additional cases diagnosed each week. The first phase of the disease , is a relapse-remitting period where the patients symptoms wax and wane [...]
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Published: June 18, 2012
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Biomaterials, Cancer Nanotechnology
ISBN: 978-1-4665-6276-9