VEGF-dependent mechanism of anti-angiogenic action of diamond nanoparticles in glioblastoma multiforme tumor

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Inhibition of tumor angiogenesis suppresses tumor growth and prevents metastasis, and is a key target in cancer therapy. Novel materials, nanoparticles of carbon allotropes (C60 fullerenes, graphite nanoparticles, multi-walled carbon nanotubes, single-walled carbon nanotubes and diamond nanoparticles) have antiangiogenic potential. However, their mechanism of action is unclear. We hypothesize that diamond nanoparticles can bind VEGF or their receptors and this way influence signal transduction between cells. Our research shows, that diamond nanoparticles has affinity to VEGF-A protein.

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Published: June 18, 2012
Pages: 218 - 221
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topicss: Biomaterials, Cancer Nanotechnology
ISBN: 978-1-4665-6276-9