Taratula O. – TechConnect Briefs

A Multifunctional Theranostic Nanoplatform for Image-Guided Surgery and Intraoperative Therapy

Taratula O., Schumann C., Duong T., Taylor K.L., Taratula O., Oregon State University, US

Currently, only optimal surgical resection of all disease sites can improve survival of ovarian cancer patients. Even with the best microsurgical techniques, however, palpation and visual inspection for malignant tissue identification can result in microscopic [...]

Toward in vivo Targeting Delivery of siRNA for Efficient Cancer Therapy

Taratula O., Kirkpatrick P., Salva R., Pandya I., Minko T., He H., Rutgers-Newark University, US

There is an increasing enthusiasm for developing therapies based on RNA interference (RNAi). However, the main obstacle in siRNA therapy is RNA delivering to the cytoplasm where it can guide sequence-specific mRNA degradation. An efficient, [...]

Labile Catalytic Packaging and Delivering of Short Interference RNA to Cancer Cells: Control of Gold Nanoparticles “out” of RNA Complexes

Chen A.M., Taratula O., Wei D., Minko T., He H., Rutgers, The State of New Jersey, US

We report a novel approach to efficiently package and deliver siRNAs with low generation dendrimers by using Au nanoparticles as a “labile catalytic” packaging agent. The Au nanoparticles helped low generation dendrimers to package siRNA [...]

Multifunctional siRNA Delivery System for Cancer Therapy

Taratula O., Salva R., Pandya I., Wang A., Minko T., He H., Rutgers-Newark University, US

The main obstacle to siRNA therapy is in delivering RNA across the cell membrane. Furthermore, new methods for monitoring therapeutic responses are highly desirable. Here we report the development of a multifunctional nanomedicine platform for [...]

Parallel Pd Nanoribbons by Spontaneous Organization of Pd Nanoparticles

Taratula O., Chen A.M., Zhang J., Chaudry J., Barnerjee I., He H., Rutgers-Newark, The State University of New Jersey, US

A simple solution phase method was used to fabricate Pd nanoribbons which are composed be an array of Pd nanoparticles separated with nanometers gaps. A remarkable feature of this method is that no templates are [...]