Carmona-Ribeiro A.M. – TechConnect Briefs

Fungicidal nanoparticles of low toxicity from cationic lipid and polyelectrolytes

Melo L.D., Carmona-Ribeiro A.M., Universidade de Sao Paulo, BR

The assembly of the cationic lipid dioctadecyldimethylammonium bromide (DODAB) and polyelectrolytes such as carboxymethylcellulose (CMC) and polydiallyldimethylammonium chloride (PDDA) produced bactericidal nanoparticles in complete absence of antibiotics. In this work, these nanoparticles are evaluated regarding [...]

Supramolecular assemblies of cisplatin and polyelectrolytes: preparation, characterization and activity against cancer cells

Vieira D.B., Kim V., Petri D.F.S., Menck C.F.M., Carmona-Ribeiro A.M., Universidade de Sao Paulo, BR

Nanoformulation of cisplatin (Cis) is important to circumvent its high toxicity against normal cells. In this work, Cis cationic nanoparticles were prepared by the self-assembly of drug and oppositely charged polyelectrolytes (carboxymethylcellulose, CMC; chitosan, CH; [...]

Polymer-based delivery vehicle for cisplatin

Vieira D.B., Menck C.F.M., Carmona-Ribeiro A.M., University of Sao Paulo, BR

Cisplatin (CisPt) is one of the most widely used agents to treat a variety of tumors, but dose-limiting toxicities or intrinsic and acquired resistance limit its application. We report a unique strategy to deliver cisplatin [...]