Papers – Page 56 – TechConnect Briefs

Dye Coded Nanoparticle as SERRS Labels for Ultrasensitive Detection of Proteins and Antibodies

Stevenson R., Stokes R.J., Ingram A., Faulds K., Graham D., The University of Strathclyde, UK

We have developed a novel surface enhanced resonance Raman scattering (SERRS) detection method that is amenable for almost any biological target. By utilising the information rich spectrum obtained from SERRS we show that we can [...]

Gold Nanoparticle Bioconjugates for Biomolecular Imaging and Detection

Liu X., Dai Q., Coutts J., Austin L., Knowles G., Huo Q., University of Central Florida, US

Gold nanoparticles and colloids have been used for a long time in biomolecular imaging and detection. With further understanding on many of the electrical and optical properties of gold nanoparticles revealed recently, the application of [...]

Local temperature measurement near remotely heated,ultra-small gold nanoparticles

Gupta A., Denver H., Borca-Tasciuc D-A., Joshi A., Kane R., Hella M., Rensselaer Polytechnic Institute, US

This work presents a novel technique to measure the temperature in the vicinity (~3.5 nm) of a remotely heated, ultra-small gold nanoparticle. The temperature measurement is carried out employing fluorescent thermometry and core/shell CdSe quantum [...]

Functionalized Mesoporous Silica Nano-particle for Optical Bio-detection

Maki G., Maki W.C., Mishra N.N., Filanoski B., Rastogi S.K., Cameron E., Maki G., Maki W.C., University of Idaho, US

Mesoporous silica nano-particles were immobilized with luciferase and antibodies for immune-bioluminescence detection of Staphylocuccus aureus enterotoxin B (SEB) and C (SEC). Mesoporous silica nano-particles were used as matrix to immobilize antibodies specific for enterotoxins and [...]

Chip-Based Energy Transfer System between Quantum dots and Gold Nanoparticles for Analysis of Protein Glycosylation

Kim H-S, Kim Y.P., Park S., Oh E., Oh Y.H., Oh E., Oh Y.H., Kim H-S, Kim Y.P., KAIST, KR

Protein glycosylation is one of the most essential processes in the living systems, and often is a major target for developing therapeutics and diagnosis. We have developed a chip-based energy transfer system between quantum dot [...]

Optimizing nanoparticle functionalization for quantum dot formation

Hooper J.B., Bedrov D., Smith G.D., Kim H., University of Utah, US

Utilizing state-of-the-art molecular dynamics simulation techniques, we have developed a methodology for determining the gross functionalization parameters required to promote formation of small, compact, and stable nanoparticle clusters in aqueous solutions. The ultimate goal of [...]

Effect of Ligand Nature on the Kinetics and the Redistribution of Quantum Dots in Mice

Daou T.J., Li L., Reiss P., Texier-Nogues I., CEA-Grenoble, FR

The meeting of nano-materials with biology has produced a new generation of technologies that can profoundly impact biomedical research. The NIR emitting window (650-900 nm) is appealing for in vivo optical imaging because of the [...]

Mechanisms of Cellular Interaction, Binding and Internalization of Functionalized Carbon Nanotubes

Lacerda L., Prato M., Bianco A., Kostarelos K., The School of Pharmacy, University of London, UK

The development of nanomaterials for biomedical and biotechnological applications is an area of research that holds great promise and intense interest. Carbon nanotubes (CNT) are thought to lead to novel types of nanomedicines. In our [...]

Synthesis of Dextran-Coated Nanoceria with pH-dependent Antioxidant Properties

Perez J.M., Asati A., Nath S., Kaittanis C., University of Central Florida, US

Cerium oxide nanoparticles (nanoceria) are potent free radical scavengers with neuroprotective, radioprotective, and anti-inflammatory properties. However, most synthetic procedures for nanoceria results in nanoparticles with poor water solubility or synthesized by procedures involving toxic solvents, [...]

Effect of functionalization on the self-assembling propensity of beta sheet forming peptides

Taraballi F., Campione M., Vescovi A.L., Sassella A., Hwang W., Paleari A., Gelain F., University of Milan-Bicocca, IT

Synthetic polymers and bioinspired fibrous materials have a significant impact in medicine in the recent years. The design and fabrication of new bio-materials has a great influence in several scientific and medical communities. The potential [...]