Materials for Drug & Gene Delivery – Page 3

Neuroprotective effects of cerebrolysin in exacerbation of blood-brain barrier breakdown, neuropathology and upregulation of nitric oxide synthase and hemeoxygenase in diabetes and hypertension after heat stroke

Muresanu D.F., Sharma A., Sharma H.S., Lafuente J.V., Nozari A., Patnaik R., Ozkizilcik A., Tian Z.R., Mössler H., Sharma A., Sharma H.S., Iuliu Hatieganu University of Medicine and Pharmacy, RO

Military personnel are often exposed to heat stress in desert areas either during peacekeeping or combat operations. In such situations, they are quite vulnerable to heat stroke and brain pathology. Due to severe work stress [...]

Novel Nano-biomaterials for Inhibition of Respiratory Syncytial Virus

Joshi S., Kirby D., Perrie Y., Singh S.R., Alabama State University, US

The liposomes were prepared using the conventional thin film hydration method with and without peptide RF-482. The loading of RF-482 was determined using BCA assay and the RSV inhibition was studied using immune-fluorescence imaging, plaque [...]

Nanodelivery of cerebrolysin reduces depressive stress induced exacerbation of Alzheimer’s disease brain pathology following amyloid-beta peptide infusion

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Patnaik R., Tian Z.R., Ozkizilcik A., Castellani R.J., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Military personnel are highly vulnerable to Alzheimer’s disease (AD). This is because of the fact that severe stress of trauma, sleep deprivation or combat stress causes increased deposition of amyloid beta peptide in the cerebrospinal [...]

Magnetically Targeted Endothelial Cells for Prevention of Vascular Restenosis

Polyak B., Drexel University, US

The advent of percutaneous transluminal angioplasty with stent implantation and the even more recent use of drug-eluting stents have resulted in a paradigm shift in the care of obstructive vascular disease. However, deleterious sequelae of [...]

Nano-magnetically targeted drug delivery system for treating Atrial Fibrillation (AF)

Harel A., NanoMed Targeting Systems Inc., US

NanoMed Targeting Systems (NTS) is developing magnetically targeted drug delivery systems for treating atrial fibrillation. This platform system is based on proprietary superparamagnetic nanoparticles attached to the payload, and its non-invasive proprietary magnetic guiding system. [...]

Conjugation of anticancer drugs with novel PEG-containing nanocarrier provides circumvention of drug-resistance mechanisms in vitro and protects of general toxicity in vivo

Kоbylinska L., Panchuk R., Skorohyd N., Senkiv Y., Heffeter P., Berger W., Boiko N., Mitina N., Zaichenko A., Lesyk R., Zіmenkovsky B., Stoika R., Vari G.S., Danylo Halytsky Lviv National Medical University, UA

In the last decade, the development of targeted drug delivery with conjugated nanoparticles brings more drug molecules to the diseased sites, at the same time reducing a systemic drug exposure. Polyethylene glycol (PEG) conjugation is [...]

Platform Reagent Development for the Intracellular Delivery of Therapeutic Peptides

Evans B.C., Lander C., Duvall C.L., Moerae Matrix, Inc., US

Peptides hold many advantages over the small molecule drugs that dominate the current healthcare market in terms of potency, specificity, and biocompatibility, and they are faster and easier to implement than genetic modifications for completion [...]

Continuous Production of Polymer Coated Drug Crystals, Particles and Nanoparticles by Hollow Fiber Membrane-based Cooling Crystallization and Anti-solvent Crystallization

Sirkar K., Chen D., Singh D., Jin C., Pfeffer R., New Jersey Institute of Technology, US

Polymeric coating can provide protection for fragile drugs from hydrolysis and degradation. With an appropriate polymer coating, nanoparticles are known to traverse the physiological human mucous barrier. Such coatings are also integral to controlled drug [...]

Nanodelivery of cerebrolysin reduces functionalized Gold Nanoparticles induced Blood-brain barrier disruption, brain edema formation and brain pathology

Sharma A., Sharma H.S., Menon P.K., Muresanu D.F., Lafuente J.V., Nozari A., Patnaik R., Ozkizilcik A., Tian Z.R., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Recently, gold nanoparticles (AuNPs) are used for drug delivery in treating several neurological disorders e.g., Alzheimer’s disease (AD), Parkinson’s disease, Stroke and trauma. In addition, use of AuNPs for diagnostic purposes in various diseases are [...]

Molecular toolkits for engineering of self-navigating drug delivery vehicles

Gillespie J.W., Auburn University, US

Analysis of multi-thousand clone populations of the cancer cell-binding landscape phages and their multi-motif proteins using massively parallel sequencing techniques allowed the discovering of a variety of short motifs serving as elementary binding units during [...]