Materials for Drug & Gene Delivery

Modeling of polypeptide- and polymer-conjugated nanoparticles for drug delivery application

Lee H.K., Dankook University, KR

Nanoparticles such as liposomes, dendrimers, and carbon nanotubes have many potential biomedical applications as antitumor therapeutics and drug delivery. These applications require the interaction of those with cell membranes, thus interactions of nanoparticles, polymers, and [...]

Bedaquiline loaded lipid nanoparticles: a promising candidate for TB treatment

Jary D., Hibbitts A., Lozano-Fernandez T., Pérez D., Lucia A., Ainsa J.A., Codony D., Freire C., Redinger N., Schaible U., Coya Raboso J.M., Tailleux L., Navarro F., CEA-LETI, FR

Increase in antibiotic resistance is a global concern worldwide[1], with 480,000 new cases of multi-drug resistant tuberculosis (MDR-TB) diagnosed each year. Therefore, the goals for the Nanotherapeutics for Antibiotic Resistant Emmerging Bacterial pathogens (NAREB) research [...]

Precise Phage-navigating Metastatic Breast Cancer-targeted Paclitaxel-Micell Nanomedicines

Petrenko V.A., Torchilin V.P., Auburn University, US

Breast cancer is one of the most common cancers in the USA. Despite the increase of relative survival rate of women with breast cancer for the last decades, it is still low (~26%, 5 years) [...]

Positively charged Ag-dendron conjugates: Stability enhanced AgNPs for biomedical applications

Cho T.J., Liu J., Hackley V.A., National Institute of Standards and Technology, US

We developed positively charged silver nanoparticles ([Ag-Ds]+), nominally 20 nm in diameter, using dendron chemistry combined with reduction of silver nitrate in the presence of sodium borohydride. The conjugate was developed within the context of [...]

Application of a Next Generation Hand Held Antimicrobial Cold Plasma Technology

Kim H., Izadjoo M., Izadjoo S., Marcel V., Truong H., Izadjoo M., Izadjoo S., Trideum Biociences and ChiScan LLC, US

Due to emergence of antibiotic and multi-drug resistant infectious agents, there is a growing need for development of novel and effective antimicrobial therapeutics and devices. Innovative anti-infective treatment modalities, particularly for multi-drug resistant infections and [...]

miRNA Expression Analysis in HEp-2 Cells after Gold Nanorod Application

Montgomery A., Bawage S., Chaudhary A., Singh S.R., Vig K., Alabama State University, US

Gold Nanoparticles are popular because of their use in drug delivery and other biomedical applications. However, not much is known about their toxicity. The purpose of the present study was to evaluate the toxicity of [...]

DEVELOPMENT OF SUSTAIN RELEASE POVIDONE IODINE OPHTHALMIC DROP THROUGH NOVEL IN-SITU GEL FORMULATION

Wei G., Gao X., Li X., Liang B., Lu Y., Baldwin J.J., Liang B., IVIEW Therapeutics Inc., US

Acute conjunctivitis (“pink eye”) is one of the most common and most contagious ocular infections seen in the United States, Japan and Europe. There are 5.9 million cases of infectious conjunctivitis annually in the United [...]

Bilayer coated ureteral stent as drug delivery platform to treat ureteric diseases

Lim W., Xiong G.M., Chong T.W., Huang Y., Venkatraman S., Nanyang Technological University, SG

The current methods of treating ureteric diseases such as strictures and carcinoma include endoscopic full-thickness incision of the ureteric wall and placement of an indwelling stent for up to 6 weeks. However, such interventions are [...]

TiO2-nanowired delivery of cerebrolysin thwarts exacerbation of sleep deprivation induced decline in regional brain derived neurotrophic factor, brain pathology and behavioral dysfunctions following emotional stress

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Nozari A., Patnaik R., Ozkizilcik A., Tian Z.R., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Sleep deprivation (SD) is a serious problem in military personnel during combat operations. Normally they have only a few hours of sleep under severe stressful conditions. This leads to profound mental and cognitive dysfunctions. Previous [...]