Biomaterials – Page 93 – TechConnect Briefs

Nanoconjugates of poly(malic acid) with functional modules for drug delivery

Ljubimova J.Y., Fujita M., Lee B-S, Khazenzon N.M., Wachsmann-Hogiu S., Farkas D.L., Black K.L., Holler E., Cedars-Sinai Medical Center, US

Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and [...]

In Vivo Tracking of Liposomes Using CT and MR Imaging

Zheng J., Liu J., Jaffray D.A., Allen C., University of Toronto, CA

Currently, there are limited methods available for longitudinal and non-invasive in vivo assessment of the transport kinetics of carrier-based therapeutics, such as those relying on liposomes. A viable strategy to non-invasively track the carrier in [...]

Nanotechnology for Drug Delivery: An Overview

Amiji M.M., Northeastern University, US

Nanotechnology is expected to have a revolutionary impact on biology and medicine. In this paper, I will discuss the role of nanotechnology in development of site-specific drug delivery systems. Polymeric nanoparticles, lipid nanosystems, and self-assembling [...]

Drug Delivery

Symmetry Dynamics in Leadership and Management

Gilberto Js., Concepcion G., Universidad Nacional Pedro Henriquez Ureña, JGC & Associates, DO

A symmetry model based on Molecular Orbital symmetry of neurotransmitters and their interaction with ion channeling effect is proposed in order to relate thiniking coordination patterns to leadership and management conditions and how can they [...]

In Silico Modification of Thermostable Lipase From Geobacillus sp. Strain T1

Rahman M.B.A., Rahman R.N.Z.A., Khan C.K., Basri M., Salleh A.B., Rahman M.B.A., Rahman R.N.Z.A., Universiti Putra Malaysia, MY

Protein cavities provide binding sites for biomolecular interaction with chemical ligands and metals. Interaction specificities and physical properties characterization of protein cavities as binding sites is the initial platform to design a semisynthetic metalloenzyme for [...]

Modelling the Microscopic Mechanisms of Sonoporation

Burns J.M., Prentice P.A., Cuschieri A., Campbell P.A., University of Dundee, UK

This work constitutes a theoretical follow up to our earlier paper in Nature Physics (November 2005) in which we demonstrate that, in the high amplutude limit, ultrasound stimulated microbubble cavitation behaviour can be approximated without [...]

DNA Translocation through a Nanopore

Qamar S., Ashcroft B., Spadola Q., Williams P., Zhang P., Lindsay S., Arizona State University, US

We are developing a technique to sequence the DNA with atomic force microsope. A single strand DNA is threaded to cyclodexrn ring and different forces are abserved as purine and oyrimidin pass through the ring. [...]

Entropy-Enhanced Genome Analysis in Frequency Domain

Lyshevski S.E., Rochester Institute of Technology, US

In this paper, we report the application of an entropy-enhanced frequency-domain analysis concept to examine large-scale genomic data. This ensures superior coherency for qualitative and quantitative analysis. Different statistical methods are used in order to [...]

Investigation of the ssDNA Backbone Molecule Mechanical Behavior Using Atomistic-Continuum Mechanics Method

Han C-N, Chou C.Y., Wu C-J, Chiang K.N., Advanced Microsystem Packaging and Nano-Mechanics Research Laboratory, National Tsing Hua University, TW

As is known, various important physiological functions and gene engineering processes, such as RNA transcription/DNA replication/DNA repair, involve specific bio-physical mechanics of DNA. Therefore, in this study, a novel single-stranded DNA (ssDNA) model based on [...]