Biomaterials – Page 51 – TechConnect Briefs

Visualization of Thyroid Cancer Signs by Atomic Force Microscopy

Reshetov I.V., Chissov V.I., Sukharev S.S., Slavnova E.N., Volchenco N.N., Bykov V.A., P.A.Hertzen Moscow Research Oncological Institute, RU

Aim: Search for the AFM signs of the thyroid cancer. Instruments and Materials: AFM-system NTEGRA Prima, NT-MDT Co., Zelenograd, Russia. Cytological specimens prepared identically to those used in traditional cytological studies. Characteristics measured: the heights [...]

Bioluminescent Model for the Quantification of Photothermal Ablative Breast Cancer Therapy Mediated by Near-Infrared Nanoparticles

Gutwein L.G., Singh A.K., Hahn M.A., Rule M.C., Brown S.C., Moudgil B., Grobmyer S.R., University of Florida, US

Multifunctional nanoparticles hold promise for enabling non-invasive image guided cancer therapy such as photothermal therapy. Human breast tumor models in which response to image guided therapy can quickly and non-invasively be determined are needed to [...]

Targeting tumor associated macrophages using clodronate-loaded PLGA nanoparticles

Sharma G., Karmali P., Ramirez M., Xie Hui, Ruoslahti E., Smith J., Burnham Institute for Medical Research, US

There is increasing evidence now that tumor associated macrophages (TAMs) play a key role in tumor growth and metastasis by promoting tumor angiogenesis. Macrophages are also prominent in tumor tissues, comprising up to 80% of [...]

Doxorubicin-loaded and Antibody-Conjugated Liposome-QD Hybrid Vesicles for Targeted Cancer Therapy and Imaging

Tian B.W., Al-Jamal W.T., Stuartb M., Kostarelos K., The School of Pharmacy, University of London, UK

In this study, we report the engineering of multimodal Liposome-QD hybrids (L-QD) for cancer imaging and therapy. L-QD hybrids were loaded with doxorubicin (Dox) using the osmotic gradient technique, achieving high encapsulation efficiency comparable to [...]

Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells

Choi Y., Torikai H., Lee D.A., Lee D.Y., Li K.C., Li Z., Lo D., Qin G., Tung C.H., Tasciotti E., Raphael R., Biswal S.L., Ang S., Lee D.A., Lee D.Y., Li K.C., Li Z., Cooper L.J.N., M.D. Anderson Cancer Center, US

we have developed a high throughput electroporator (HiTE) to manipulate large numbers (~10^9) of T cells ex vivo for clinical uses. HiTE is designed to electro-transfer RNA species to redirect T-cell specificity and gold nanoparticles [...]

Detection of Cancer Related DNA Nanoparticulate Biomarkers and Nanoparticles in Whole Blood

Heller M.J., Krishnan R., Sonnenberg A., University of California San Diego, US

The ability to rapidly detect DNA nanoparticulate biomarkers and drug delivery nanoparticles directly in blood is a major challenge for early disease detection and nanomedicine. We now show that a microarray dielectrophoretic (DEP) device can [...]

Cancer Nanotechnology

Sensitivity of Detection by Biological AFM for Gold-Labeled Liposomes at Human Coronary Artery Endothelial Cell (HCAEC) Membranes

Zaske A.M., Danila D., Queen M.C., Golunski E., Conyers J.L., University of Texas Health Science Center at Houston, US

Engineering of non-toxic nanoparticles for tissue-specific targeting has gained widespread attention this decade. Liposomes were one of the earliest classes of engineered nanoparticles to be utilized for the purpose of delivering drugs within the human [...]

A proof of concept: a model of targeted stealth nanoparticles that are stable and biocompatible for RNA interference in vivo to macrophages

Yusuf M.S., Miller A.D., Prata C.H., Imperial College Gene Therapies Centre, UK

Bringing together advances generated through the developing fields of bionanotechnology and gene therapy, and demonstrated through the ABCD model, we propose a biocompatible, stable, specific stealth lipoplex targeting macrophages, as proof of concept, which is [...]

An Intracranial Neurocompatible Nanocomposite Polymeric Device for the Chronic Management of AIDS Dementia Complex

Khan R.A., Harilall S-L., Pillay V., Choonara Y.E., du Toit L.C., Modi G., Naidoo D., Iyuke S., Integral University, IN

This study focused on the design, biometric simulation and development of a biodegradable Composite Intracranial Nano-enabled Device (CIND) for the intracranial delivery of zidovudine (AZT) in the treatment of AIDS Dementia Complex (ADC), a common [...]