Medical & Biotech – Page 76 – TechConnect Briefs

Qdot® nanocrystals in intracellular flow: ZAP-70, KI-67 and five-colors fluorophores panel

Sotnikov I., Jaron S., Konopleva M., O’Brien S., Andreeff M., Hildebrant J., Manis J., Brown J., Vorobjev I., Barteneva N., Immune Disease Institute, Harvard Medical School, US

We present, for the first time, the methodological approach for the measurement of cytoplasmic Zap-70 and nuclear Ki-67 proteins with Qdot® nanocrystals-labeled antibodies. Mononuclear cells from chronic lymphoid leukemia patients were used to detect Zap-70, [...]

Nano Medical Sciences

Nanomaterials Employed in Effective Tumor Treatment

Liang X-J., National Center for Nanoscience and Technology of China, CN

Chemotherapy is one of most effective cures to treat different of malignant tumors. Cisplatin is a chemotherapeutic compound commonly used in clinics, however, acquired resistance confines its application in chemotherapeutics. To overcome the acquired resistance [...]

Development of new thermo-ablation therapy using magnetic nanoparticles and device for alternating magnetic field

Hashimoto S., Oda T., Yamada K., Ohara Y., Ohkohchi N., Kanamori T., Ikehata Y., Nagano I., Yanagihara H., Kishimoto M., Kita E., University of Tsukuba, JP

Although induction heating cancer therapy (IHCT) using magnetic nanoparticles can be a promising approach to treatment-less multi-nodular cancers, combination of conventional super paramagnetic particle (SPIO) and standard alternating magnetic field (AMF) generator confer insufficient heat [...]

Zebrafish as a universal in vivo model for plasmonic nanoparticle medicine

Lukianova-Hleb E., Santiago C., Wagner D., Hafner J., Lapotko D., Rice University, US

In vivo application of plasmonic methods faces serious challenges because standard animal models are not well suited for optical activation and detection of plasmonic effects and for precise control the distribution and interactions of the [...]

Multimodality therapy: Enhancement of melanoma cell death with combination of heat shock protein 90 inhibitor, 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG), and gold nanoparticles in a noninvasive radiofrequency field

Kaluarachchi W.D., Curley S.A., M.D. Anderson Cancer Center, US

Melanoma is the most deadly form of skin cancer. Hyperthermia has been used to treat advanced stage melanoma. However, solid tumors often respond minimally to hyperthermic treatment due to the thermo-tolerance induced by chaperons of [...]

Multifunctional Fe3O4/ZnO core-shell nanoparticles for photodynamic therapy

Beltran J.C., Tomar M.S., Singh S.P., Perales O., Rivera L., Peña S., University of Puerto Rico-Mayagüez, PR

The photodynamic therapy (PDT) based on core-shell structures require efficient luminescence within specific wavelength range, preferably in near infrared. In the present study we aim to create a multifunctional platform for PDT through Fe3O4/ZnO core [...]

Anti-K-Ras siRNA to Treat Pancreatic Cancer

Julien D.C., Giri A., Papasani M., Murdoch G., Hrdlicka P., Hill R.A., University of Idaho, US

Cancer of the pancreas is a leading cause of cancer-related mortality. Chemotherapeutic drugs used to treat pancreatic cancers are toxic and minimally effective, yielding a 1-4% 5-year survival rate after initial diagnosis. Approximately 90% of [...]

Minimal-dose cancer chemotherapy: Anti-cancer drugs loaded nanodevices towards time, site, and organ-specific releases for development of personalized nanomedicine

Khan R.A., Newati S.J., Singh V.M., Sachdeva S., Sharma R., Manav Rachna International University (MRIU), IN

The objective of the present study was to develop a site specific, time controlled and organ targeted anti-cancer drug delivery nanosystem comprising of nano-particles of polymeric origins for treatment of cancer in minimum dose regimen. [...]

Halloysite Clay Nanotubes: Characterization, Biocompatibility and Use as Drug Carriers

Vergaro V., Abdullayev E., Zeitoun A., Giovinazzo G., Santino A., Cingolani R., Lvov Y.M., Leporatti S., National Nanotechnology Laboratory (NNL) of CNR-INFM, IT

Halloysite nanotubes (HNTs) are efficient nano-containers capable of entrapping a range of active agents within the inner lumen, followed by their retention and slow release. Halloysite is a green environmentally friendly object available in commercial [...]