Medical & Biotech – Page 119 – TechConnect Briefs

Automated 3D cortex image data acquisition

Lich B.H., Knott G., FEI Electron Optics, NL

The study of the 3D architecture of cortex tissue requires the creation of image data sets with sufficient detail in all directions. The detail level required to produce meaningful data requires imaging quality that allows [...]

Nano Neuro Knitting: using nanotechnology to repair the brain

Ellis-Behnke R.G., Liang Y-X, You S-W, Tay D.K.C., Zhang S., So K-F, Schneider G.E., Massachusetts Institute of Technology, US

Nanotechnology is often associated with materials fabrication, microelectronics, and microfluidics; using nanotechnology and molecular self-assembly in biomedicine to repair injured brain structures had never been explored. To achieve axonal regeneration after injury in the CNS, [...]

Using Electron Tunneling for Direct Sequencing of DNA

Lund J., Dong J., Mehta R., Rahimi M., Ryan D., Parviz B.A., University of Washington, US

Genomic information has assumed a central role in the way biology in general and cell function in particular are understood today. Methods that can sequence DNA rapidly, accurately, and cost-effectively are needed in order to [...]

Optimizing Quantum Dot-Conjugated Immunoliposomes for Cancer Diagnostics and Targeted Therapeutics

Weng K.C., Noble C.O., Papahadjopoulos-Sternberg B., Chen F.F., Park J.W., UCSF Comprehensive Cancer Center, US

A multifunctional nanoparticle that combines the optical properties of luminescent quantum dots (QDs) and therapeutic modality of immunoliposomes (ILs) has been developed. Carboxylate-derivatized QDs cross-linked with amino- poly(ethylene glycol)-functionalized liposomes were modified with anti-human epidermal [...]

Nanomedicine: Engineering of a Tri-Imageable Nanoparticle

Bumb A., Brechbiel M.W., Choyke P., Fugger L., Dobson P.J., National Cancer Instiute and University of Oxford, UK

We have created a potential targeted drug delivery platform with three imaging reporters by coupling the magnetic properties of USPIOs with near infrared fluorescence of Cy5.5 and gamma emissions of Indium-111 that is chelated to [...]

Nano Medicine

Sirna Nanomedicines for Cancer Gene Therapy

Kim S-H, Park T.G., Korea Advanced Institute of Science and Technology, KR

We developed a polyelectrolyte complex (PEC) micelle-based delivery system for treatment of prostate cancer. A PEGylated siRNA targeting human vascular endothelial growth factor (hVEGF) was synthesized. The hVEGF expression was almost completely inhibited in vitro [...]

Development of a specific micro/nanodevice validating the concept of molecular biopsy

Berger F., Bouamrani A., Cosnier M., Martin F., Caillat P., Benabid A.L., Inserm, FR

The nanomedicine concept implies early detection at the molecular level and molecular characterisation to implement a specific therapy. In this context, the development of micro/nanotool devoted for intra-tissular characterisation is indispensable. We first demonstrated that [...]

Characterization and in vivo efficacy of targeted nanoparticles for systemic siRNA delivery to tumors

Bartlett D.W., Davis M.E., California Institute of Technology, US

This abstract highlights the results from our latest work in the design and application of targeted nanoparticles for systemic siRNA delivery. Over the past several years, we have performed extensive physicochemical and biological characterization of [...]

Development of Nanoconjugate with Different Monoclonal Antibodies to Inhibit Molecular Targets Important for Tumor Angiogenesis

Fujita M., Khazenzon N.M., Lee B-S, Holler E., Black K.L., Ljubimova J.Y., Cedars-Sinai Medical Center, US

Tumor cell-specific drug targeting is the major goal of nanotechnology-based platforms. A nanoconjugate Polycefin was synthesized for targeted delivery of antisense oligonucleotides and antibodies into tumors. The delivery of antisense oligonucleotides to α4 and β1 [...]