Development of Nanoconjugate with Different Monoclonal Antibodies to Inhibit Molecular Targets Important for Tumor Angiogenesis

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Tumor cell-specific drug targeting is the major goal of nanotechnology-based platforms. A nanoconjugate Polycefin was synthesized for targeted delivery of antisense oligonucleotides and antibodies into tumors. The delivery of antisense oligonucleotides to α4 and β1 chains of a vascular basement membrane protein, laminin-8, suppressed its synthesis in vivo. Treatment of glioma-bearing rats significantly diminished tumor vascularity (p

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Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 20, 2007
Pages: 760 - 762
Industry sector: Medical & Biotech
Topicss: Biomaterials, Cancer Nanotechnology
ISBN: 1-4200-6183-6