Using Electron Tunneling for Direct Sequencing of DNA

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Genomic information has assumed a central role in the way biology in general and cell function in particular are understood today. Methods that can sequence DNA rapidly, accurately, and cost-effectively are needed in order to expand our knowledge of the core biology and realize the promise of genomics in areas such as personalized medicine. Here, we report an electronic method that can directly read bases using inelastic electron tunneling spectroscopy without any chemical manipulation or labeling of DNA. We have experimentally validated our method using a scanning tunneling microscope (STM) and have made nanoelectrodes separated by a 2 nm gap for performing the sequencing on a chip.

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Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 20, 2007
Pages: 780 - 783
Industry sector: Medical & Biotech
Topics: Biomaterials, Cancer Nanotechnology
ISBN: 1-4200-6183-6