nanoparticles – Page 23 – TechConnect Briefs

Enrichment of serum phosphopeptide by nanoparticles to identify cancer biomarker

Shah A., Sachdev V., Bharti A., Boston University Medical School, US

The role of kinases in transformation and cancer progression is established. We hypothesize that The role the specific phosphoproteins/phosphopeptides will be present in cancer patient serum as leak proteins and their isolation and identification will [...]

Functionalized Inorganic Nanostructures for Biomedical Applications

Bonroy K., Jans H., Jans K., Van de Broek B., Van Meerbergen B., Van Summeren A., Jans H., Jans K., Reekmans G., Van de Broek B., Van Meerbergen B., Van Summeren A., Van de Broek B., Van Meerbergen B., Van Summeren A., Huang C., Stakenborg T., Trekker J., Willems M., Bartic C., Verhaegen K., Borghs G., IMEC, BE

Nanomaterials differ significantly from other materials due to two factors: increased surface area and quantumsize effects. These factors can enhance properties such as reactivity, strength and physical characteristics. Due to these characteristics, the coupling of [...]

Towards nanosized particles in pharmaceutical industry

Bieri N.R., Meier U., Goncalves E., Zimmermann D., Juhnke M., Thakur R., Novartis Pharma AG, CH

The pharmaceutical industry is facing the problem of an increasing number of drug substances in development which are either poorly water soluble or show pH dependency of solubility. Drug targeting and tailored delivery poses additional [...]

Influence of Nanoparticles on the Nervous Tissue Properties

Reshetov I.V., Chissov V.I., Sukharev S.S., Timoshenko V.Y., Sidletskiy V.Y., Forsh P.A., P.A.Hertzen Moscow Research Oncological Institute, RU

Interaction between the nanoparticles and nervous tissue in the process of the damage healing is the object of study in the present work. Laboratory animal (rat) was put into deep narcosis. The Nervus ischiadicus was [...]

Experimental evaluation of individual protection devices against nanoaerosols:

Golanski L., Rouillon F., Guiot A., Bernard S., Tardif F., CEA, FR

Analysts have estimated that the worldwide market for nanoparticles will be about 340 billion Euro in 2011 which would rank it alongside the automobile and microelectronic industries. However, potential impact of these new materials on [...]

Exposure to nanoparticles collected in the Los Angeles basin in California leads to the up regulation to brain associated genes

Ljubimova J.Y., Kleinman M.T., Khazenzon N.M., Fujita M., Rudenkyy S., Ospital J., Wallerstein B., Meacher D., Gookin G., Salazar K., Black K.L., Cedars-Sinai Medical Center, US

Direct evidence regarding brain tumors as a result of exposure to specific chemical agents and particulate air pollutants is limited. We wanted to determine the size of nanoparticles from Los Angeles basin in California, coarse [...]

Cytotoxicity of bare and PEGylated silica nanoparticles as potential gene-delivery vectors

Yagüe C., Saldaña L., Martin F., Arruebo M., Vilaboa N., Santamaria J., Universidad fe Zaragoza, ES

Silica and other inorganic carriers are one of the major groups used to transport drugs and bioactive molecules into cells. The others are viral carriers, organic cationic compounds and recombinant proteins. The use of mesoporous [...]

Upconverting nanoparticles for photodynamic therapy

Chatterjee D.K., Zhang Y., National University of Singapore, SG

Photodynamic therapy involves killing of diseased cells by excitation of photosensitizer chemicals with high energy light to produce cytotoxic oxygen species from surrounding dissolved oxygen. However, poor tissue penetration of high energy light and hydrophobic [...]

5-aminolevulinic Acid Conjugated Gold Nanoparticles for Cancer Treatment

Khaing Oo M.K., Yang X., Wang H., Du H., Stevens Institute of Technology, US

To improve 5- aminolevulinic acid’s (5-ALA) selective retention in tumor cells and efficient damage tumor cells in photodynamic therapy (PDT), biocompatible gold (Au) nanoparticles were proposed as the carrier to selectively deliver 5-ALA into tumor-like [...]

Gold Nano-Probes as Targeted CT Contrast Agents for In-vivo cancer Imaging

Popovtzer A., Popovtzer R., Agrawal A., Shlomi M., Popovtzer A., Popovtzer R., Balter J., Carey T.E., Kopelman R., University of Michigan, US

This research describes a new class of immuno-targeted and cancer specific CT contrast agents, which enable CT imaging of cancer at cellular and molecular resolution. The method is based on the development of gold nano-probes [...]