nanoparticles – Page 22 – TechConnect Briefs

Identification of bacterial susceptibility to antibiotics using gold nanoparticles

Perez J.M., Kaittanis C., Nath S., University of Central Florida, US

Inexpensive and rapid methods for detecting bacterial infections and their corresponding susceptibility to antibiotics are desperately needed. The determination of which antibiotic to use and its administration at dosages that will effectively suppress bacterial growth [...]

Use of Nanoparticles as Therapy for Respiratory Syncytial Virus Inhibition

Vig K., Boyoglu S., Rangari V., Sun L., Singh A., Singh S.R., Pillai S., Singh A., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus is the leading cause of severe respiratory illnesses such as bronchiolitis and pneumonia in young children. RSV is a paramyxovirus with negative-sense genomic RNA that encodes for eleven proteins, two of which, [...]

Upconverting nanoparticles for in vitro and in vivo cellular imaging

Chatterjee D.K., Zhang Y., National University of Singapore, SG

Conventional fluorescent labels are of limited in vivo utility because short-wavelength radiation penetrates tissues poorly and excites strong background autofluorescence. Upconversion nanoparticles (UCN) convert low-energy exciting photons to visible emissions, resulting in deep tissue penetration [...]

Potential anti-inflammatory properties of biologically-synthesized nanoparticles of gold or silver

Vercruysse K.P., Harper S.L., Ivory D.M., Whalen M.M., Saili K.S., Tanguay R.L., Tennessee State University, US

Ionic gold (Au) compounds have been used for many years in the treatment of rheumatoid arthritis (aurotherapy). Despite their long history, the basis for their therapeutic properties has never been established definitively. We have observed [...]

Nanoparticle-enhanced Magnetic Field Induces Apoptosis in Nematode

Huang G.S., Yeh L.K., Chen Y-C, National Chiao Tung University, TW

To investigate molecular consequence of magnetic field to C. elegans, Fe3O4 nanoparticles were incorporated into the culture media of C. elegans and the nematodes were grown under magnetic field for 4 days. For the expermental [...]

Landscape phage libraries as a source of bioselective nanomaterials

Kuzmicheva G.A., Sorokulova I.B., Jayanna P.K., Petrenko V.A., Auburn University, US

New generations of targeted diagnostic, therapeutic and imaging nanodevices require robust molecular recognition interfaces, which bind their targets with high specificity and selectivity. These bioselective interfaces can be formed by recombinant filamentous phages or their [...]

Modulating affinity of landscape phage nanoparticles by mutagenesis of the major coat protein

Kuzmicheva G.A., Eroshkin A.M., Potemkin V.A., Petrenko V.A., Auburn University, US

Phage peptide libraries proved to be invaluable source of the ligands specifically binding numerous analytes. Diversity and repertoir of the libraries are critical for the successful selection of ligands. In landscape libraries guest peptides are [...]

Molecular Imaging by Nanoparticle Bacterial delivery Systems:

Sharma R., University of North Carolina, Greensboro, US

Dynamic observations have driven the course of imaging biology ever since the first bacterial motility was observed in the late sixteenth century. Continuous imaging of time dependent bacterial motion events is a rapidly emerging biomedical [...]

Invention of Polysaccharide-base Nanoparticles for Enhancing Drug Permeability across the Blood Brain Barrier

Gil E.S., Lowe T.L., Pennsylvania State University, US

The primary objective of this study is to evaluate novel cationic and degradable beta-cyclodextrin nanoparticles as drug delivery carriers for insulin across the bovine brain microvessel endothelial cell (BBMVEC) monolayer, an in vitro blood brain [...]

Development of Peptide Nucleic Acid Assemblies for Application in Drug Delivery and Molecular Sensing

Butler F.N., Elibol O., Hines B.D., Reddy Jr. B., Bashir R., Bergstrom D.E., Purdue University, US

We are exploring peptide nucleic acid (PNA) assemblies as interesting scaffolds for the fabrication of nanomaterials relevant to the diagnosis and treatment of disease. The first assembly is a PNA/LNA (locked nucleic acid) duplex employed [...]