in vivo – TechConnect Briefs

Enhancement of anticancer action of traditional (doxorubicin and cisplatin) and experimental (landomycin A) drugs by their delivery in vivo with novel C60-fullerene-based nanocarriers possessing innate ROS-modulating activity

Panchuk R., Prylutska S., Skorokhyd N., Lehka L., Skivka L., Hurmach V., Evstigneev M., Piosik J., Berger W., Prylutskyy Yu., Scharff P., Stoika R., Vari S., Institute of Cell Biology NAS of Ukraine, UA

Rapid development of multi-drug resistance of tumor cells to chemotherapy caused by the over-expression of specific ABC-transporter proteins and/or multiple defects in genes involved in cell cycle and apoptosis regulation in cancer cells frequently leads [...]

Preparation of ion group functionalized diblock copolymers and examination of their thermogelling properties

Lee B.K., Kwon D.Y., Kwon J.S., Park J.H., Kwon D.Y., Kwon J.S., Kim J.H., Kim M.S., Oh S.H., Kim J.H., Kim M.S., Ajou University, KR

To investigate thermogelling behavior, in this study, methoxy polyethylene glycol-b-[poly(ε-caprolactone)-ran-poly(6-chloride-ε-caprolactone) (PCL-ran-PfCL)] (PCL-Cl) diblock copolymers were designed such that the PfCL content in the PCL segment was varied. The PCL-Cl diblock copolymers were derivatized by introducing [...]

Preparation of ion group functionalized diblock copolymers and examination of their thermogelling properties

Lee B.K., Kwon D.Y., Kwon J.S., Park J.H., Kwon D.Y., Kwon J.S., Kim J.H., Kim M.S., Oh S.H., Kim J.H., Kim M.S., Ajou University, KR

To investigate thermogelling behavior, in this study, methoxy polyethylene glycol-b-[poly(ε-caprolactone)-ran-poly(6-chloride-ε-caprolactone) (PCL-ran-PfCL)] (PCL-Cl) diblock copolymers were designed such that the PfCL content in the PCL segment was varied. The PCL-Cl diblock copolymers were derivatized by introducing [...]

Bio-compatibility of silver nanomaterials using the embryonic zebrafish bioassay

Fisher J.A., Tanguay R.L., Oregon State University, US

The bio-compatibility of silver nanomaterials (AgNP) is currently of great interest to regulators and health and safety professionals because it is a material that has the potential to reach mass populations. Four well characterized (Harper [...]

CNS Regeneration After Chronic Injury Using a Self-assembled Nano Material

Liang Y-X, Cheung S.W.H., Chan K.C.W., Wu E.X., Tay D.K.C., Ellis-Behnke R.G., Medical Faculty Mannheim of the University of Heidelberg, DE

To speed up the process of central nervous system (CNS) recovery after injury, the need for real-time measurement of axon regeneration in vivo is essential to assess the extent of injury, as well as the [...]

In Vivo Real Time Raman Spectroscopy Detection of Carbon Nanotube Kinetics in Lymph, Blood and Tissues

Biris A.S., Galanzha E.I., Li Z., Mahmood M., Xu Y., Dervishi E., Zharov V.P., University of Arkansas at Little Rock, US

The development of novel therapies using unique nanostructures for molecular targeting has become a major area of biological research. Here, we present the first report of the use of carbon nanotubes (CNTs) as high contrast [...]

Improved Tissue Distribution, Renal Clearance and Toxicity Profile of Functionalised Carbon Nanotubes

Lacerda L., Prato M., Bianco A., Kostarelos K., The School of Pharmacy, University of London, UK

Carbon nanotube (CNT) development for biomedical applications is in the nascent stages, however is thought to lead to novel types of diagnostic, therapeutic and regenerative nanomedicines. The construction of CNT-based delivery systems able to traffick [...]

Keywords: in vivo

Enhancement of anticancer action of traditional (doxorubicin and cisplatin) and experimental (landomycin A) drugs by their delivery in vivo with novel C60-fullerene-based nanocarriers possessing innate ROS-modulating activity

Preparation of ion group functionalized diblock copolymers and examination of their thermogelling properties

Preparation of ion group functionalized diblock copolymers and examination of their thermogelling properties

Bio-compatibility of silver nanomaterials using the embryonic zebrafish bioassay

CNS Regeneration After Chronic Injury Using a Self-assembled Nano Material

In Vivo Real Time Raman Spectroscopy Detection of Carbon Nanotube Kinetics in Lymph, Blood and Tissues

Improved Tissue Distribution, Renal Clearance and Toxicity Profile of Functionalised Carbon Nanotubes

Temperature Sensitive Liposomes for Local Drug delivery Using Focused Ultrasound

Real-time Detection and Quantitation of siRNAs in vivo

Delivery systems for enhanced siRNA delivery