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Modulating affinity of landscape phage nanoparticles by mutagenesis of the major coat protein

Kuzmicheva G.A., Eroshkin A.M., Potemkin V.A., Petrenko V.A., Auburn University, US

Phage peptide libraries proved to be invaluable source of the ligands specifically binding numerous analytes. Diversity and repertoir of the libraries are critical for the successful selection of ligands. In landscape libraries guest peptides are [...]

Phage Probes for Cancer Diagnostic and Treatment

Samoylova T.I., Morrison N.E., Cox N.R., Auburn University, US

Phage display is a powerful discovery tool with a variety of applications including identification of peptides that specifically recognize and bind to cell-surface targets. Phage particles carrying such peptides have the potential to serve as [...]

Targeting Nanoparticle Probes to Differentiating Stem Cells

Cabral-Teixeira J., Benjamin K., Zhang L., Maurer J., Tsuda M., Chao Y.S., Prigozhina N., Price J., Snyder E., Mercola M., Ruoslahti E., West M.D., Larocca D., Advanced Cell Technology, US

Pluripotent stem cells offer great potential for treating diseases where cells are lost to injury or disease processes. The ability to specifically label progenitor cells in populations of differentiating stem cells will provide a powerful [...]

Real-time Detection and Quantitation of siRNAs in vivo

Cheng A., Liang Y., Vlassov A., Li M., Liang Y., Wang Y., Wong L., Chen C., Cheng A., Magdaleno S., Ambion Inc., An Applied Biosytems Business, US

We have developed TaqMan based RT-PCR assays to detect and quantitate siRNAs in vivo. These assays can be used to measure siRNA delivery efficiency after injections and follow body distribution. These assays can also be [...]

DNA-Associated Single-walled Carbon Nanotubes as a Platform for Drug Delivery

Dolash B.D., Lahiji R.R., Zemlyanov D.Y., Reifenberger R., Bergstrom D.E., Purdue University, US

DNA-associated single walled carbon nanotubes(DNA:SWCNTs) have shown potential in drug delivery with the ability to translocate across the cell membrane carrying various biomolecules. Our laboratory has completed a series of experiments to show the sonication [...]

Step and Flash Imprint Lithography for the Fabrication of Shape-specific, Enzymatically-triggered, Drug Nanocarriers

Caldorera-Moore M., Glangchai L.C., Shi L., Roy K., The University of Texas at Austin, US

Current concepts in the synthesis of nanocarriers primarily involve the use of polymers or lipids to fabricate self-assembled or emulsion-based particles that are mostly spherical, polydisperse, and release drugs through diffusion or hydrolysis. Although significant [...]

Lyceum Chinense and Calcium Phosphate Nanoparticles for Ophthalmic Drug Delivery

He Q., Fang Z., Wang M., Xu Q.W., Chen R., Zhang X.Z., Yaun W.M., Zhau D.M., Wu Jian, Morehouse School of Medicine, US

Glaucoma, the leading cause of irreversible blindness in the world, is estimated to be affected by 67 million people. It is characterized by an increase in intraocular pressure (IOP). Carbonic anhydrase inhibitors (CAIs) are orally [...]

Synthesis of magnetic nanoparticles and its applications in drug delivery systems

Wright Bolden N., Rangari V., Jeelani S., Tuskegee University, US

Summary An improved method of drug delivery is much needed in areas such as cancer therapy in which more drugs needs to be delivered to a specific site and non-specific toxicities should be minimal. Drug [...]

Molecular Imaging by Nanoparticle Bacterial delivery Systems:

Sharma R., University of North Carolina, Greensboro, US

Dynamic observations have driven the course of imaging biology ever since the first bacterial motility was observed in the late sixteenth century. Continuous imaging of time dependent bacterial motion events is a rapidly emerging biomedical [...]

Invention of Polysaccharide-base Nanoparticles for Enhancing Drug Permeability across the Blood Brain Barrier

Gil E.S., Lowe T.L., Pennsylvania State University, US

The primary objective of this study is to evaluate novel cationic and degradable beta-cyclodextrin nanoparticles as drug delivery carriers for insulin across the bovine brain microvessel endothelial cell (BBMVEC) monolayer, an in vitro blood brain [...]