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Gold nanoparticles and emerging applications in imaging

Sharma A., Sharma R., Sharma A., Sharma R., Florida State University, US

Au from Au–Ag core–shell nanoparticles acts as multimodal Gold-speckled silica nanoparticles as contrast agents for noninvasive imaging with magnetic resonance imaging and photoacoustic tomography. These Au nanopeanuts can be prepared in a simple one-pot synthesis [...]

Copper 64-Cu nanoparticles in multimodal imaging of carotid artery disease

Sharma A., Sharma R., Sharma A., Sharma R., Florida State University, US

Nanoparticle based hybrid imaging by MRI, PET-CT and Fluorescent reflectance techniques are emerging in imaging carotid artery disease. 64Cu-TNP is detectable by MRI and PET-CT. A trimodality reporter 64Cu-TNP is a derivatization product made of: [...]

Analysis of an Optofluidic Biochemical Sensor

Furlani E.P., Biswas R., Litchinitser N.M., University at Buffalo, US

In this presentation we introduce a novel optofuidic biochemical sensor in which detection is based on the contrast between the refractive index of a target biomaterial and the ambient carrier fluid. The sensor consists of [...]

Integrated lab-on-a-chip Influenza diagnostic designed for low cost manufacturing

Sauer-Budge A.F., Mirer P.L., Chatterjee A., Klapperich C.M., Sharon A., Fraunhofer USA, US

In this paper we describe a completely integrated lab- on-a-chip for genetic analysis of bacteria or viruses. The chip was designed for low cost manufacturing in thermoplastics by choice of low cost materials (thermoplastics) and [...]

Multiplexed protein detection using antibody-conjugated microbead arrays assembled on a microfabricated electrophoretic device

Barbee K.D., Hsiao A.P., Roller E.E., Huang X., UCSD, US

We report the development of a microfabricated electrophoretic device for assembling high-density arrays of antibody-conjugated microbeads for chip-based protein detection. The device consists of a flow cell formed between a gold-coated silicon chip with an [...]

Microfluidic Devices for Rapid Separation and Sensing of Cells

Bose S., Lee C.H., Karp J.M., Karnik R., Massachusetts Institute of Technology, US

We report a new method to separate cells in microfluidic devices by directing the trajectories of cells along asymmetric receptor edges. This approach relies on cell rolling, a physiological phenomenon involving transient interactions of the [...]

Magnetic Nanotag-based Immunoassay for Multiplex Mycotoxin Detection

Mak A.C., Osterfeld S., Yu H., Wang S., Davis R.W., Jejelowo O.A., Pourmand N., Stanford University, US

Rapid, sensitive and multiplexed measurement is vital in molecular diagnostics such as cancer diagnosis and pathogens detection. While highly specific and sensitive, traditional immunochemical assays such as enzyme-linked immunosorbent assays (ELISAs) often require expensive read-out [...]

Nanoparticle-coated nanosprings for diagnostic applications using SERS based detection

Sai V.V.R., University of Idaho, US

Significant enhancements in the SERS signals may be obtained with elongated arrangement of silver or gold nanoparticles. Silica nanosprings (NS) with high surface to volume ratio are promising candidate to yield such sensor materials. In [...]

Label-Free, Electrical Detection of the SARS Virus N-Protein with Nanowire Biosensors Utilizing Antibody Mimics as Capture Probes

Chang H.K., Ishikawa F., Chiang P.C., Zhou C., University of Southern California, US

In this report, we introduce evolved AMPs as a new class of capture agents for nanowire/nanotube biosensors, and demonstrate selective detection of a protein related to severe acute respiratory syndrome (SARS), using devices based on [...]

Towards an asynchronous magnetic bead rotation method for immunological assays

Hecht A., Kinnunen P., McNaughton B., Kopelman R., University of Michigan, US

Much attention has been focused on using magnetic particles for biodetection applications on chip. Most of these applications involve using the magnetic particles either for translational motion in a magnetic field, or as labels for [...]