Papers:
Alginate/Montmorillonite nancomposites for the delivery of curcumin
Curcumin is a well-known traditional medicine with anti-inflammatory and antioxidant properties. Its pharmacological mechanism of action and safety have been studied to investigate its use in clinical and therapeutic applications. However, its low water solubility [...]
Molecular toolkits for engineering of self-navigating drug delivery vehicles
Analysis of multi-thousand clone populations of the cancer cell-binding landscape phages and their multi-motif proteins using massively parallel sequencing techniques allowed the discovering of a variety of short motifs serving as elementary binding units during [...]
Nanodelivery of cerebrolysin reduces functionalized Gold Nanoparticles induced Blood-brain barrier disruption, brain edema formation and brain pathology
Sharma A., Sharma H.S., Menon P.K., Muresanu D.F., Lafuente J.V., Nozari A., Patnaik R., Ozkizilcik A., Tian Z.R., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE
Recently, gold nanoparticles (AuNPs) are used for drug delivery in treating several neurological disorders e.g., Alzheimer’s disease (AD), Parkinson’s disease, Stroke and trauma. In addition, use of AuNPs for diagnostic purposes in various diseases are [...]
Continuous Production of Polymer Coated Drug Crystals, Particles and Nanoparticles by Hollow Fiber Membrane-based Cooling Crystallization and Anti-solvent Crystallization
Polymeric coating can provide protection for fragile drugs from hydrolysis and degradation. With an appropriate polymer coating, nanoparticles are known to traverse the physiological human mucous barrier. Such coatings are also integral to controlled drug [...]
Platform Reagent Development for the Intracellular Delivery of Therapeutic Peptides
Peptides hold many advantages over the small molecule drugs that dominate the current healthcare market in terms of potency, specificity, and biocompatibility, and they are faster and easier to implement than genetic modifications for completion [...]
Conjugation of anticancer drugs with novel PEG-containing nanocarrier provides circumvention of drug-resistance mechanisms in vitro and protects of general toxicity in vivo
Kоbylinska L., Panchuk R., Skorohyd N., Senkiv Y., Heffeter P., Berger W., Boiko N., Mitina N., Zaichenko A., Lesyk R., Zіmenkovsky B., Stoika R., Vari G.S., Danylo Halytsky Lviv National Medical University, UA
In the last decade, the development of targeted drug delivery with conjugated nanoparticles brings more drug molecules to the diseased sites, at the same time reducing a systemic drug exposure. Polyethylene glycol (PEG) conjugation is [...]
Nano-magnetically targeted drug delivery system for treating Atrial Fibrillation (AF)
NanoMed Targeting Systems (NTS) is developing magnetically targeted drug delivery systems for treating atrial fibrillation. This platform system is based on proprietary superparamagnetic nanoparticles attached to the payload, and its non-invasive proprietary magnetic guiding system. [...]
Magnetically Targeted Endothelial Cells for Prevention of Vascular Restenosis
The advent of percutaneous transluminal angioplasty with stent implantation and the even more recent use of drug-eluting stents have resulted in a paradigm shift in the care of obstructive vascular disease. However, deleterious sequelae of [...]
Nanodelivery of cerebrolysin reduces depressive stress induced exacerbation of Alzheimer’s disease brain pathology following amyloid-beta peptide infusion
Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Patnaik R., Tian Z.R., Ozkizilcik A., Castellani R.J., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE
Military personnel are highly vulnerable to Alzheimer’s disease (AD). This is because of the fact that severe stress of trauma, sleep deprivation or combat stress causes increased deposition of amyloid beta peptide in the cerebrospinal [...]
Novel Nano-biomaterials for Inhibition of Respiratory Syncytial Virus
The liposomes were prepared using the conventional thin film hydration method with and without peptide RF-482. The loading of RF-482 was determined using BCA assay and the RSV inhibition was studied using immune-fluorescence imaging, plaque [...]
Neuroprotective effects of cerebrolysin in exacerbation of blood-brain barrier breakdown, neuropathology and upregulation of nitric oxide synthase and hemeoxygenase in diabetes and hypertension after heat stroke
Muresanu D.F., Sharma A., Sharma H.S., Lafuente J.V., Nozari A., Patnaik R., Ozkizilcik A., Tian Z.R., Mössler H., Sharma A., Sharma H.S., Iuliu Hatieganu University of Medicine and Pharmacy, RO
Military personnel are often exposed to heat stress in desert areas either during peacekeeping or combat operations. In such situations, they are quite vulnerable to heat stroke and brain pathology. Due to severe work stress [...]
TiO2-nanowired delivery of cerebrolysin thwarts exacerbation of sleep deprivation induced decline in regional brain derived neurotrophic factor, brain pathology and behavioral dysfunctions following emotional stress
Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Nozari A., Patnaik R., Ozkizilcik A., Tian Z.R., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE
Sleep deprivation (SD) is a serious problem in military personnel during combat operations. Normally they have only a few hours of sleep under severe stressful conditions. This leads to profound mental and cognitive dysfunctions. Previous [...]
Bilayer coated ureteral stent as drug delivery platform to treat ureteric diseases
The current methods of treating ureteric diseases such as strictures and carcinoma include endoscopic full-thickness incision of the ureteric wall and placement of an indwelling stent for up to 6 weeks. However, such interventions are [...]
DEVELOPMENT OF SUSTAIN RELEASE POVIDONE IODINE OPHTHALMIC DROP THROUGH NOVEL IN-SITU GEL FORMULATION
Acute conjunctivitis (“pink eye”) is one of the most common and most contagious ocular infections seen in the United States, Japan and Europe. There are 5.9 million cases of infectious conjunctivitis annually in the United [...]
miRNA Expression Analysis in HEp-2 Cells after Gold Nanorod Application
Gold Nanoparticles are popular because of their use in drug delivery and other biomedical applications. However, not much is known about their toxicity. The purpose of the present study was to evaluate the toxicity of [...]
Application of a Next Generation Hand Held Antimicrobial Cold Plasma Technology
Kim H., Izadjoo M., Izadjoo S., Marcel V., Truong H., Izadjoo M., Izadjoo S., Trideum Biociences and ChiScan LLC, US
Due to emergence of antibiotic and multi-drug resistant infectious agents, there is a growing need for development of novel and effective antimicrobial therapeutics and devices. Innovative anti-infective treatment modalities, particularly for multi-drug resistant infections and [...]
Positively charged Ag-dendron conjugates: Stability enhanced AgNPs for biomedical applications
We developed positively charged silver nanoparticles ([Ag-Ds]+), nominally 20 nm in diameter, using dendron chemistry combined with reduction of silver nitrate in the presence of sodium borohydride. The conjugate was developed within the context of [...]
Journal: TechConnect Briefs
Volume: 3, Biotech, Biomaterials and Biomedical: TechConnect Briefs 2017
Published: May 14, 2017
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 978-0-9988782-0-1