Papers – Page 27 – TechConnect Briefs

Polymalic acid-based nanodrugs: Anti-tumor efficacy and host compatibility

Holler E., Ding Hui, Patil R., Portilla J., Inoue S., Gangulum P., McNeil S.E., Patri A., Dobrovolskaia M.A., Black K.L., Ljubimova J.Y., Cedars-Sinai Medical Center, US

A polyanionic drug carriers is presented that penetrates biobarriers and targets molecular cancer markers of human breast and brain cancer. The carrier platform is poly(beta-L-malic acid) (PMLA), which is highly water soluble and biodegradable to [...]

Immunodiagnosis for cervical cancer using antibody-gold nanoparticle conjugate

Tapaneeyakorn S., Thepthai C., Apiwat N., Dharakul T., National Science and Technology Development Agency, TH

Cervical cancer is a leading cause of cancer deaths among women. It is most often caused by persistent infections with high-risk human papillomavirus (HPV). Since current screening programs are either complex or costly to run, [...]

EGF conjugated gold and silver nanoparticles for imaging EGFR over-expressing cells

Lucas L.J., Hewitt K.C., Dalhousie University, CA

Purpose: To create and validate a novel SERS-based nanoprobe for optical imaging of the epidermal growth factor receptor (EGFR). Experimental Design: Gold and silver nanoparticles (Au/AgNPs) were synthesized and coupled to epidermal growth factor (EGF) [...]

A Nanopore Biomimetic Device Quantitatively Detects Early Stage Cancer Cells; a Contour Map Multiple Variable Correlation Method Assesses the Heat of Cancer Cells Released

Chen E.T., Shen J. Thornton Y., Ngatchou C., Duh S-H, Kissinger P.T., Advanced Biomimetic Sensors, Inc., US

Detecting low abundance cancer cell is challenged by the complex instrumentation and time consuming assays. We report a unique cancer cell detection device that is capable of detecting low abundance MDA-MB-231 breast cancer cells based [...]

Encapsulation and Characterization of BSA in PLA-PEG Nanoparticles as a Model for Chlamydia trachomatis rMOMP-278 Protein Nanovaccine Delivery System

Taha M., Singh S.R., Moore C., Agee R., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is a major human health pathogen because it is the most reported sexually transmitted disease. There is no effective mucosal vaccine against Chlamydia. One of the major problems of the C.trachomatis vaccine development [...]

In vitro anticancer activity of poly(3-hydroxybutyrate) nanoparticles loaded with antitumor drug Paclitaxel

Yakovlev S.G., Bonartsev A.P., Bonartseva G.A., Bagrov D.V., Efremov Yu.M., Boskhomdzhiev A.P., Filatova E.V., Ivanov P.V., Makhina T.K., Bonartseva G.A., A.N.Bach’s Institute of Biochemistry Russian Academy of Sciences, RU

We have produced nanoparticles loaded with antitumor drug paclitaxel. Operated nanospheres were prepared on the base of a biodegradable and biocompatible polymer of bacterial origin, poly(3-hydroxybutyrate) (PHB). PHB nanoparticles with paclitaxel (230±55 nm in diameter) [...]

Orally Delivered Polymeric nanoparticles of Lopinavir: Development and Statistical optimization, in vitro and ex vivo studies

Joshi G., Sawant K.K., M S University of Baroda, IN

Nanoparticles (NPs) have been extensively studied for oral drug delivery. NPs are taken up intact by M cells of peyer’s patches of gut associated lymphoid tissue (GALT) followed by its systemic circulation thereby preventing first [...]

Supramolecular assemblies of cisplatin and polyelectrolytes: preparation, characterization and activity against cancer cells

Vieira D.B., Kim V., Petri D.F.S., Menck C.F.M., Carmona-Ribeiro A.M., Universidade de Sao Paulo, BR

Nanoformulation of cisplatin (Cis) is important to circumvent its high toxicity against normal cells. In this work, Cis cationic nanoparticles were prepared by the self-assembly of drug and oppositely charged polyelectrolytes (carboxymethylcellulose, CMC; chitosan, CH; [...]

Self Assembled Nanostructures of Triblock Co-polymer and Plasmid DNA for Gene Delivery

Daima H.K., Shankar P.R. Selvakannan S., Bhargava S.K., Bansal V., RMIT University, AU

In present work, we have used tri-block copolymer (PEO-PPO-PEO) as a non-viral vector to deliver plasmid DNA (pDNA). Green fluorescence protein (GFP) plasmid DNA was used as a model plasmid DNA. Addition of pDNA to [...]

Nanostructured cellulose materials: adsorption of antibiotics onto cellulose fibers functionalized with glycidylmethacrylate for the manufacturing of antibacterial fabrics

Vismara E., Torri G., Valerio A., Graziani G., Montanelli A., Melone L., Politecnico di Milano, IT

Abstract: In this work we report how cotton fibers can be easily functionalized with glycidylmethacrylate (GMA) by means of the Fenton’s reaction and used for the manufacturing of biomedical textiles having significant capability to adsorb [...]