Papers – Page 28 – TechConnect Briefs

Designing Responsive Materials with Chemically Amplified Sensitivity to NIR light

Fomina N., McFearin C., Sermsakdi M., Morachis J., Almutairi A., University of California at San Diego, US

We employ near infrared (NIR) light as an external trigger for controlled material degradation and targeted release of a payload. NIR light can penetrate through tissues to an appreciable depth without scattering or damaging it. [...]

Electrospun Nanofibrous Scaffold for Controll Drug Delivery

Leung V., Hartwell R., Faure E., Yang H., Ghahary A., Ko F., University of British Columbia, CA

This study aims to design methods for controlling drug release from polymer nanofibres, and use these methods as a guide for designing nanofibre wound dressings with customizable release profile for a range of drugs. The [...]

Surfactant Effect on Intercellular Transport of DNA, Proteins, and Electrolytes

Assan D., Gao X., Lai J.C.K., Leung S.W., Idaho State U, US

Surfactants play a key role on bodily functions at molecular level, such as cell signaling and signal transmission. Their importance in cell survival is well recognized, but the surfactant effect on intermolecular/interfacial mass transport is [...]

Development of PHEMA-Chitosan nanospheres and encapsulation of RSV-F DNA vaccine

Eroglu E., Waffo A.B., Dennis V.A., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus (RSV) causes serious lower respiratory tract diseases among infants. Unfortunately, no effective vaccine to prevent RSV infection has been developed. RSV fusion gene (RSV-F) is conserved among various strains of RSV. Therefore, [...]

Sequential Surface Functionalization by Polyoxometalates and Lysine Renders Non-toxic Gold Nanoparticles Strong Antibacterial Agents

Daima H.K., Selvakannan P.R., Bhargava S.K., Bansal V., RMIT University, AU

Gold nanoparticles (AuNPs)are considered as biocompatible and important component for biomedical applications. In current study, AuNPs were synthesised using tyrosine amino acid mediated reduction of gold ions. These nanoparticles were functionalised with two polyoxometalates (POMs) [...]

Controlled- Release Antibiotic Nanoparticles for Cranial Transplantation and Bone Grafting

Adusumilli A.N., Dammalapati S., Fu P.K.-L., Governors State University, US

The objective of this research is to develop a unique nanoparticulate system that is capable of delivering antibiotics in a locally applied and extended-release manner for patients receiving cranial replacement implants and bone grafting. This [...]

Surface Functionalized Multicomponent Envelope Type Nanosystems for Improved Gene Delivery

Pozzi D., Orlando V., Augusti Tocco G., Biagioni S., Cardarelli F., Bifone A., Caraccioloa G., Sapienza University of Rome, IT

Recently, a new programmed packaging strategy in which various “soft devices” that control intracellular trafficking are incorporated into single nanoparticles has been proposed. Here we apply such a novel concept to develop multicomponent envelope-type nanosystems [...]

Dual Modal Gene Expression and Silencing Using Viral/Nonviral Chimeric Nanoparticles for Synergistic Gene Therapy

Cho S.K., Luu T., Wong S., Kwon Y.J., UC Irvine, US

Efficient, safe, and versatile gene delivery carriers that combine the viral vectors’ high gene delivery efficiency and the nonviral vectors’ high level of flexibility for structural and functional modifications were prepared. Adeno-associated virus (AAV) was [...]

A Novel Single Step Method of Synthesizing Large Unilamellar Liposomes for Biomedical Applications

Phapal S.M., Sunthar P., Indian Institute of Technology - Bombay, IN

We have investigated various coacervation techniques for liposome synthesis. The aim is to study various local mixing conditions and their effect on the size of liposomes formed. To control the extent of mixing, four different [...]

Drug Delivery with Light-Activated Gold-Coated Liposomes

Orsinger G.V., Leung S.J., Knights S.S., Williams J.D., Romanowski M., University of Arizona, US

With the ultimate goal of delivering therapeutic compounds selectively to cancerous or diseased tissues and cells, we have presented liposome-based plasmon resonant nanocapsules. The described biocompatible composite delivery vehicle enables encapsulation and selective release of [...]