Papers – Page 21 – TechConnect Briefs

Quantum Dots as a Unique Nanoscaffold to Mimic Membrane Receptor Clustering

Anikeeva N., Gakamsky D., Sykulev Yu., Thomas Jefferson University, US

We utilized quantum dots (QD) as a unique nanoscaffold with uniform size and well-defined structure to assemble membrane immune receptors on the surface of the dots at desired density. Such QD/receptor biosensors appear to be [...]

Effects of Chitosan and Nanoparticles on Survival of Schwann Cells and Dorsal Root Ganglion Neurons

Lai J.C.K., Gao W., Leung S.W., Idaho State University, US

We have systematically examined the effects of chitosan film or chitosan in combination with nanometal particles (nanogold or nanosilver particles) on the growth of Schwann cells (S16) and DRG neurons (50 B 11). Results of [...]

The mechanical sensitivity of vesicle dynamics in in vivo and in vitro neurons

Ahmed W., Li T., Rubakhin S., Chiba A., Sweedler J., Saif T.A., University of Illinois at Urbana-Champaign, US

To study the mechanical response of both in vivo and in vitro neurons, we have developed a novel platform for in-situ high-resolution live-imaging of cells and tissues under applied mechanical strain. The system is capable [...]

Lipid nanoparticles: tumor-targeting nanocargos for drug and contrast agent delivery

Delmas T., Navarro F., Gravier J., Thomann J.S., Heinrich E., Mérian J., Fraichard A., Boisgard R., Tavitian B., Dufort S., Coll J.L., Bibette J., Boisseau P., Couffin A.C., Texier I., CEA-Grenoble, FR

A new technology for the encapsulation of lipophilic molecules -both drugs and contrast agents dedicated to chemotherapy, phototherapy, or fluorescence imaging in oncology- has been developed, based on oil-in-water nanoemulsions. Thorough physico-chemical characterizations of the [...]

Polymersome macromolecule delivery across intact human skin

Pegoraro C., MacNeil S., Battaglia G., University of Sheffield, UK

Skin is a highly stratified and impermeable tissue that confers specific size, charge, hydrophilic and lipophilic constraints on the types of molecules that can diffuse across it. Here we report the use of a novel [...]

CNS Regeneration After Chronic Injury Using a Self-assembled Nano Material

Liang Y-X, Cheung S.W.H., Chan K.C.W., Wu E.X., Tay D.K.C., Ellis-Behnke R.G., Medical Faculty Mannheim of the University of Heidelberg, DE

To speed up the process of central nervous system (CNS) recovery after injury, the need for real-time measurement of axon regeneration in vivo is essential to assess the extent of injury, as well as the [...]

Cytotoxic studies of PEG functionalized ZnO Nanoparticles on MCF-7 cancer cells

Rodriguez Martinez C., Ramirez Vick J.E., Perales O., Singh S.P., University of Puerto Rico-Mayagüez, US

Nanoparticles have shown great promise in biomedical applications. Zinc oxide (ZnO) nanoparticles are being explored for various applications such as sun screen lotion, antimicrobial properties, advanced textiles, photodynamic therapy and electronic devices. We have synthesized [...]

Sulfur-33 Nanoparticles: A Possible Target for Neutron Capture Therapy of Cancer

Porras I., University of Granada, ES

Sulfur nanoparticles, enriched in the isotope S-33 are potential neutron capturers for enhancing neutron radiation dose in tumors, because of a nuclear reaction of this isotope which produces a high energy alpha particle which delivers [...]

In-vitro testing of realgar nanoparticles for treatment of multiple myeloma cells

Balaz P., Sedlak J., Pastorek M., Cholujova D., Bujnakova Z., Institute of Geotechnics, Slovak Academy of Sciences, SK

Realgar As4S4 has been used in traditional Chinese medicine externally or even orally to treat psoriasis,syphilis and malaria.However,its broader healing effect was documented recently.The possibility to synthesize realgar particles as nanosuspensions brings new therapeutic strategies [...]

Investigation of Taxol effects on morphological and micromechanical properties of human endometrial adenocarcinoma cells by AFM

Kim J.H., Kim K.S., Cho C.H., Choi Y.J., Kim J.H., Kim K.S., Choi Y.J., Jung G.B., Jung M-H, Yoon K-S, Woo Lee J., Lee G.J., Jung G.B., Jung M-H, Park H.K., Kyung Hee University, KR

The effects of Taxol on morphological and micromechanical properties of human endometrial adenocarcinoma (Ishikawa cell), were investigated by atomic force microscopy (AFM). The morphological and mechanical properties of the Ishikawa cell were significantly changed by [...]