Papers – Page 51 – TechConnect Briefs

Modulating affinity of landscape phage nanoparticles by mutagenesis of the major coat protein

Kuzmicheva G.A., Eroshkin A.M., Potemkin V.A., Petrenko V.A., Auburn University, US

Phage peptide libraries proved to be invaluable source of the ligands specifically binding numerous analytes. Diversity and repertoir of the libraries are critical for the successful selection of ligands. In landscape libraries guest peptides are [...]

Targeted Drug-carrying Filamentous Phage Nanomedicines

Yacoby I., Bar H., Vax L., Benhar I., Tel Aviv University, IL

We present a novel application of filamentous bacteriophages as targeted drug carrying nanomedicines. The phages are engineered to display target-specificity-conferring peptides or proteins on their coat, and carry a large payload of a cytotoxic drug [...]

Phage Probes for Cancer Diagnostic and Treatment

Samoylova T.I., Morrison N.E., Cox N.R., Auburn University, US

Phage display is a powerful discovery tool with a variety of applications including identification of peptides that specifically recognize and bind to cell-surface targets. Phage particles carrying such peptides have the potential to serve as [...]

Targeting Nanoparticle Probes to Differentiating Stem Cells

Cabral-Teixeira J., Benjamin K., Zhang L., Maurer J., Tsuda M., Chao Y.S., Prigozhina N., Price J., Snyder E., Mercola M., Ruoslahti E., West M.D., Larocca D., Advanced Cell Technology, US

Pluripotent stem cells offer great potential for treating diseases where cells are lost to injury or disease processes. The ability to specifically label progenitor cells in populations of differentiating stem cells will provide a powerful [...]

Real-time Detection and Quantitation of siRNAs in vivo

Cheng A., Liang Y., Vlassov A., Li M., Liang Y., Wang Y., Wong L., Chen C., Cheng A., Magdaleno S., Ambion Inc., An Applied Biosytems Business, US

We have developed TaqMan based RT-PCR assays to detect and quantitate siRNAs in vivo. These assays can be used to measure siRNA delivery efficiency after injections and follow body distribution. These assays can also be [...]

Studies of conformational changes induced in a carrier protein: Bovine serum albumin

El Kadi N., Taulier N., Urbach W., Waks M., Paris V, FR

Defective folding diseases have emerged in the last decade as prevalent in an ageing population. In this respect any increased knowledge of folding mechanisms could be crucial for preventing, treating or even curing these neurodegenerative [...]

DNA-Associated Single-walled Carbon Nanotubes as a Platform for Drug Delivery

Dolash B.D., Lahiji R.R., Zemlyanov D.Y., Reifenberger R., Bergstrom D.E., Purdue University, US

DNA-associated single walled carbon nanotubes(DNA:SWCNTs) have shown potential in drug delivery with the ability to translocate across the cell membrane carrying various biomolecules. Our laboratory has completed a series of experiments to show the sonication [...]

Step and Flash Imprint Lithography for the Fabrication of Shape-specific, Enzymatically-triggered, Drug Nanocarriers

Caldorera-Moore M., Glangchai L.C., Shi L., Roy K., The University of Texas at Austin, US

Current concepts in the synthesis of nanocarriers primarily involve the use of polymers or lipids to fabricate self-assembled or emulsion-based particles that are mostly spherical, polydisperse, and release drugs through diffusion or hydrolysis. Although significant [...]

Preparation And Evaluation Of In Vitro Release Of Amphiphilic _-Cyclodextrin Or Pla Nanospheres Containing A Hydrophobic Drug

Lin S., Lahiani-Skiba M., Naouli N., Lahiani-Skiba M., Skiba M., Université de Rouen, FR

Mebendazole (MBZ) is an antihelmintic which belongs to group of benzimidazols. It is used for many intestinal diseases and for other diseases. But its low absorption, its high dosages caused side effects on gastro-intestinal track, [...]

Evaluation of the paromomycin loading characteristics in nanoprecipitated PLGA nanospheres

Kalimouttou S., Lahiani-Skiba M., Naouli N., LIN V.S., Lahiani-Skiba M., Skiba M., Université de Rouen, FR

The aim of this work was to optimize the preparation of poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with paromomycin by a nanoprecipitation technique. PLGA was choosen because of its biodegradability and biocompatibility features. In order to [...]