Evaluation of the paromomycin loading characteristics in nanoprecipitated PLGA nanospheres

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The aim of this work was to optimize the preparation of poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with paromomycin by a nanoprecipitation technique. PLGA was choosen because of its biodegradability and biocompatibility features. In order to improve the delivery system, especially the drugs loading efficiency, the influences of the amount of polymer and the volume of the organic phase on the characteristics of the nanospheres were assessed. Physico-chemical characterization of the loaded nanoparticles was performed.

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Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2008: Life Sciences, Medicine & Bio Materials – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: June 1, 2008
Pages: 407 - 410
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 978-1-4200-8504-4