Papers – Page 30 – TechConnect Briefs

Detection and Localization of Antibody-Antigen Interactions with High Spatial Resolution on Collagen Tendons

Boyd R.D., Avci R., Schweitzer M., Wittmeyer J., Spangler B., Thieltges K.M., Cranfield University, UK

Measuring ligand receptor forces using the atomic force microscope as a force-sensing instrument has been well documented. For example in the detection of antibody-antigen interactions with the antibody attached to the AFM tip with a [...]

DNA repair enzyme analysis on EWOD fluidic microprocessor

Jary D., Chollat-Namy A., Fouillet Y., Boutet J., Chabrol C., Castellan G., Gasparutto D., Peponnet C., CEA, FR

DNA repair enzyme analysis on EWOD fluidic microprocessor An original analytical assay, aimed at monitoring DNA lesions repair activities has been combined to a dedicated microfluidic EWOD (electrowetting on dielectric) microprocessor.The quantification of enzymatic repair activities [...]

Compact Disc (CD)-Based Automated Animal Assay

Kim N.H., Dempsey C.M., Zoval J., Sze J.Y., Madou M.J., University of California Irvine, US

Microfabricated platforms that allow automated cultivation and behavioral observation of Caenorhabditis elegans would be a valuable tool in physiological and genetic studies. Here, we report an automated microfluidic compact disc (CD) system conducive to the [...]

Mixed-Methodology-Based System-Level Simulation of Biochemical Assays in Integrated Microfluidic Systems

Wang Y., Bedekar A.S., Krishnamoorthy S., Siddhaye S.S., Sundaram S., CFD Research Corporation, US

While lab-on-a-chip (LoC) systems are increasingly used in the areas of genomics, proteomics and drug discovery, their efficient simulation and design at system-level continue to be a challenge. Experimental trial-and-error and multiphysics-based high fidelity computation [...]

Coin-Shaped Reactor in Microfluidic Devices Used for Radiopharmaceutical Synthesis

Elizarov A.M., Kolb H.C., van Dam R.M., Heath J.R., Padgett H.C., Huang J., Daridon A., California Institute of Technology, US

A microfluidic device designed and optimized for the multi-step synthesis of PET (Positron Emisssion Tomography) probes is presented. It is the first device in its class to produce radiopharmaceuticals of sufficient quality and quantity (over [...]

Integrated microfluidic device to monitor the cells acidification rate in nanoliter volumes using microfabricated iridium oxide electrodes

Ges I.A., Ivanov B.L., Baudenbacher F.J., Vanderbilt University, US

In our work we describe a new approach to measure pH differences in microfluidic devices and demonstrated acidification rate measurements in on-chip cell culture systems with nanoliter wells. We used two miniaturized identical iridium oxide [...]

Thermally Induced Marangoni Instability of Liquid Microjets with Application to Continuous Inkjet Printing

Furlani E.P., Price B.G., Hawkins G., Lopez A.G., Eastman Kodak Co., US

Liquid microjets are inherently unstable and can be broken into droplets in a controllable fashion via thermal modulation of surface tension. Such modulation can be achieved using CMOS/MEMS technology by integrating resistive heating elements around [...]

Analysis of the Droplet Ejection for Piezoelectric-driven Industrial Inkjet Head

Sim S., Park C., Park S-J, Park C., Park S-J, Yoo Y., Kim Y., Joung J., Oh Y., Samsung Electro Mechanics Co., KR

A hybrid design tool combining one-dimensional(1D) lumped parameter model and three-dimensional(3D) computational fluid dynamics (CFD) approach has been developed and applied to industrial inkjet head design for the application of direct writing on printed circuit [...]

Magnetohydrodynamic (MHD) Complex Flow Generation in Microchannel

Kim D.S., Kwon T.H., Pohang University of Science and Technology (POSTECH), KR

In this paper, we present design methodologies for magnetohydrodynamic (MHD) complex flow generation in a simple straight microchannel in which electrodes are patterned on two side walls and bottom wall. The required applied voltage conditions [...]

Capillary filling speed in silicon dioxide nano-channels

Jarlgaard S.E., Mikkelsen M.B.L., Skafte-Pedersen P., Bruus H., Kristensen A., Technical University of Denmark, DK

We present a simple silicon-based fabrication technique for nanocapillaries based on controlled growth of silicon-dioxide, UV lithography, etching with etch-stop, and glass wafer bonding. Our approach improves state-of-the-art with respect to the obtained cross-wafer homogeneity [...]