Papers – Page 29 – TechConnect Briefs

Full Coupling Simulation of a Membrane Micropump

Yao Q., Xu D., Pan L.S., Melissa Teo A.L., Ho W.M., Peter Lee V.S., Shabbir M., Institute of High Performance Computing, SG

The design of PZT actuated valveless membrane micropumps is a very complex process as it involves the knowledge of electro mechanics, solid mechanics and fluid mechanics. So far, there is no accurate, flexible and broadly [...]

Computational experiments on three-dimensional molecular diffusion in porous media

Alarcon V.J., Kingery W., Zhu J., Mississippi State University, US

Estimations of apparent diffusion coefficients usually consist of curve-fitting the output of one-dimensional models to experimental laboratory-measured data from porous aggregates shaped in different forms. In this research a computational exploration is presented on the [...]

Simulation of a Microfluidic Particle Concentrator and Separator

Chen C.C., Auner G.W., Industrial Technology Research Institute, TW & Wayne State University, US

A flow-through micro polymerase chain reaction (PCR) chip was optimized by using coupled multiphysics computational tools. Comprehensive simulations of temperature and flow profiles were presented for the denaturation, extension, and annealing zones on the flow-through [...]

Simulation and Optimization of a Flow-Through Micro PCR Chip

Kang J., Chen C.C., Smolinski J., Thomas R.A., Tucker J.D., Auner G.W., Industrial Technology Research Institute, TW & Wayne State University, US

We present a microfluidic particle concentrator and separator employing a large flow unit array. Each flow unit includes a nozzle, a sharp turn, a diffuser, and a flow dividing segment. After acceleration in the nozzle, [...]

Computationally Efficient Models of Flow-through Affinity-based Assays

Peterson D.K., Wright W.H., MacQueen D.B., SRI International, US

Lateral flow “strips” are a common assay format used in a variety of applications, including home pregnancy testing, clinical point-of-care screening for HIV, agribusiness surety against pathogens, and military bioagent detection. Current lateral flow assays [...]

Microchannel Mixing, Entropy and Multifractals

Kaufman M., Camesasca M., Manas-Zloczower I., Cleveland State University, US

Microfluidic systems operate in a pressure driven flow regime with no moving parts to drag the fluids. Our research aims at developing rigorous assessment and quantification tools of mixing in microchannels. The tools are based [...]

AC Electroosmotic Fluid Flow in Electrolytes Generated by Two Coplanar Microelectrodes

Adamiak K., University of Western Ontario, CA

AC electroosmotic pumping of fluids is studied in the model consisting of two thin coplanar electrodes, deposited on a dielectric substrate and placed in an aqueous solution. An AC voltage is supplied to the electrodes [...]

A Continuous Particle/Cell Sorter Using Dielectrophoresis

Wang G.R., Feng J.J., Vasantgadkar S., Pant K., Prabhakarpandian B., Krishnamoorthy S., Sundaram S., CFD Research Corporation, US

We present a novel design of a continuous microfluidic sorter for separation of cells or particles by the intelligent use of conventional negative dielectrophoresis with separation efficiency of greater than 95%. A high fidelity modeling [...]

Optimizing antibody microarrays for high resolution SPR microscopy

Kim G., Nishimoto A., Cong S., Johnson E., Guan H.W., Petcavish B., Lasky S., Hood L., Campbell C.T., Lumera Corporation, US

A high resolution surface plasmon resonance (SPR) microscopy technique based on the combination of Lumera’s polymer and proprietary optic technologies offers parallel high-throughput analysis of biomolecular binding kinetics on high-density antibody microarrays ( > 1,500 [...]

Fast and Efficient Nucleic Acid Testing by ST‘s In-CheckTM Lab-on-Chip Platform

Conoci S., Di Francesco F., Di Pietro P., Di Trapani G., Petralia S., Amore M.G., San Biagio F., Alaimo G., Iacono G., Alessi E., Ricceri D., Di Francesco F., Di Pietro P., Di Trapani G., Di Francesco F., Di Pietro P., Di Trapani G., Palmieri M., STMicroelectronics, IT

Nucleic Acid Testing (NAT) represents one the most sensitive and effective method for several applications in the molecular diagnostic area, including clinical, industrial, veterinary and research applications. In this context, the development of miniaturized devices [...]