Papers – Page 30 – TechConnect Briefs

Modelling Free Jet Ejection on a System Level – An approach for microfluidics

Koltay P., Moosmann C., Litterst C., Streule W., Birkenmeier B., Zengerle R., University of Freiburg, DE

Fast simulation of complex microfluidic systems requires consideration of network simulations based on lumped models as an alternative to standard computational fluid dynamic (CDF) simulations. In this paper we describe an analytical model of an [...]

Transient Filling Flow into Microchannels Considering Surface Tension

Kim D.S., Lee K-C, Lee S.S., Kwon T.H., Lee K-C, Lee S.S., Pohang University of Science and Technology, KR

In this paper, we investigated, both experimentally and numerically, transient “filling” flow into microchannels, which differs from completely “filled” flow in micro-channels. An experimental flow visualization system was devised to observe the characteristics of microchannel [...]

End Effects of Rare Gas Flow in Short Channels and in Squeezed-Film Dampers

Veijola T., Helsinki University of Technology, FI

Simple approximate design formulas (+-5%) for calculating the elongation of the idealized viscous flow channel of rare gas at Knudsen numbers Kn < 100 due to the open end effects. Rectangular channels with a large [...]

Viscous Dissipation Effects For Liquid Flow In Microchannels

Xu B., Ooi K.T., Mavriplis C., Zaghloul M.E., Nanyang Technological University, SG

Different phenomena have been observed in various works indicating that the mechanisms of flow and heat transfer in microchannels are still not understood clearly. There is little experimental data and theoretical analysis in the literature [...]

Simulation Methodology for Dielectrophoresis in Microelectronic Lab-on-a-chip

Leonardi A., Medoro G., Manaresi N., Tartagni M., Guerrieri R., DEIS - University of Bologna, IT

Recent trends in lab-on-a-chip show a growing use of dielectrophoresis (DEP) to manipulate biological objects such as cells and organic molecules [1], [2], [3], [4]. Bringing the advances of microelectronic miniaturization into biological and clinical [...]

Biochemical Binding in Microspheres-Based-Imunoassays

Prabhakarpandian B., Shah K.B., Sundaram S., Makhijani V.B., CFD Research Corporation, US

Microspheres (referred commonly as beads) are being extensively used in biochemical assays as supports for proteins, DNA, etc. We have successfully developed computational models for simulating sample detection using flowing beads. The model fully integrates [...]

Macromolecules in Microdevices: Multiscale simulation of DNA dynamics in model microfluidic geometries

Jendrejack R.M., de Pablo J.J., Graham M.D., University of Wisconsin-Madison, US

Simple arguments predict that the dynamics of a dissolved macromolecule confined to a channel comparable to its equilibrium coil size (~1 um for viral DNA) are quite different from those in free solution, because of [...]

Separation of Long Polyelectrolytes in a Microfuluidic Channel with Constrictions: A Monte Carlo Study

Tessier F., Slater G.W., University of Ottawa, CA

We present Monte Carlo simulation results for the motion of long linear polyelectrolytes inside a microchannel of molecular dimensions, structured as a periodic array of wells linked by narrow constrictions. Molecules are driven in the [...]

Modeling of Joule Heating in Electrophoretic Separation Microchips

Wang Y., Lin Q., Hoburg J.F., Mukherjee T., Carnegie Mellon University, US

This paper presents a model for Joule heating induced analyte dispersion in electrophoretic separation channels with a rectangular cross section. The model is in closed form and captures the effect of cross-sectional geometry. Three-dimensional numerical [...]

Analysis of Physico-Chemical Processes in an Amperometric Oxygen Biosensor

Krishnamoorthy S., Feng J.J., Makhijani V.B., Gao C., Choi J.W., Ahn C., CFD Research Corporation, US

Amperometric techniques are commonly used in lab-on-a-chip systems to sense various blood gas analytes such as H+, CO2, O2, etc. In the present study, a microchip-based amperometric biosensor, being developed as a part of plastic-based [...]