Micro & Bio Fluidics, Lab-on-Chip – Page 51

Simulation of Droplet Formation in Micromixers

Hardt S., Schönfeld F., Weise F., Hofmann C., Ehrfeld W., Institut für Mikrotechnik, DE

Droplet formation in micromixers developed by the Institute of Microtechnology Mainz (IMM) is investigated by methods of computational fluid dynamics (CFD). The CFD results are compared to experimental data obtained with transparent micromixers made from [...]

Modeling of Blood Flow in Simple Microchannels

Trebotich D., Chang W., Liepmann D., University of California-Berkeley, US

Optimal design of medical micro-assay systems will require computational modeling capabilities. Most existing models are based on macroscale experiments with smallest length dimensions comparable to that of a capillary due to the fact that the [...]

Electrodynamic Transport, Electroporation and Lysis of Cells in Pharmacological and Bioanalytical Microsystems

Przekwas A.J., Chen Z.J., Athavale M., CFD Research Corporation, US

Biological information is stored in cells and is the prime object of interest of pharmacological, biomedical, and bioanalytical professionals. Whatever the interest: elcectroporative drug delivery and pharmacodynamics, in vivo PCR, infection pathology, DN

Inverted Method for Simulation of Electrokinetic Transport in Microchannel Devices

Nilson R.H., Griffiths S.K., Sandia National Laboratories, US

An inverted method of solution is used to numerically solve the equations governing electrokinetic fluid flow and species transport in microscale turns, junctions and curved channels. Rather than solving for the electric potential and fluid [...]

Analysis of Sample Transport in Capillary Electrophoresis Microchip Using Full-Scale Numerical Analysis

Krishnamoorthy S., Feng J.J., Makhijani V.B., CFD Research Corporation, US

An implicit finite-volume numerical scheme has been developed to solve the three-dimensional transport equations along with fully-coupled ionization equilibria in acid/base systems. The scheme solves conservation equations for mass and momentum while satisfying the electroneutrality [...]

Numerical Modeling of Magnetic Field Flow Fractionation in Microchannels: A Two-fold Approach Using Particle Trajectories and Concentration

Berthier J., Pham P., Massé P., LETI, FR

Submicronic paramagnetic particles are currently used for biological applications like medical diagnostic [1]. Recently modeling of displacement of such particles has seen new developments like the calculation of the trajectory of a particle [2], or [...]

Mixed-Dimensionality, Multi-Physics Simulation Tools for Design Analysis of Microfluidic Devices and Integrated Systems

Przekwas A.J., Makhijani V.B., CFD Research Corporation, US

Computational design of microfluidic devices and integrated microsystems involves several strongly coupled physical disciplines, including fluid mechanics, heat transfer, stress/deformation dynam-ics, electrokinetics, biochemistry and others. CFDRC is dev

Efficient Numerical Methods for the Simulation of Flow Reactors

Becker R., Braack M., Heuveline V., Rannacher R., University of Heidelberg, DE

We describe recent developments in the design of numerical methods for the simulation of heat transport and chemical processes in ow reactors. For viscous ow in the low-Mach-number regime, we use a stable finite element [...]

Electroosmotic Microfluidic Flows with Random Zeta Potential

Gleeson J.P., University College Cork, IR

Average electroosmotic ows in the presence of axially-varying zeta potentials are shown to be plug-like, with variances which depend on radial position across the capillary. Consequences for the dispersion of samples are examined theoretically and [...]

Surface Tension Induced Instability of Viscous Liquid Jets

Furlani E.P., Delametter C.N., Chwalek J.M., Trauernicht D., Eastman Kodak Company, US

Viscous liquid jets are inherently unstable, and drop formation can be induced by various means including surface tension modulation. Furthermore, surface tension is temperature dependent, and can be modulated by locally heating the surface of [...]