Materials for Drug & Gene Delivery – Page 20

In Vivo Toxicity Study of Gold Composite Nanodevices for use in Imaging and Radiotherapy

Khan M.K., Nair B., Kasturirangan V., Kariapper M.S.T., Nigavekar S.S., Toth K., Rustum Y.M., El-Jawahri A., Bizimungu R., Lesniak W., Balogh L.P., Roswell Park, US

We previously reported on the in vitro toxicity assessment of differently charged dendrimer-gold nanocomposites on normal cells (human endothelial cells) and prostate cancer cells (Khan et al., 2008). In this study we evaluate the in [...]

Drug Delivery

Real-time Detection and Quantitation of siRNAs in vivo

Cheng A., Liang Y., Vlassov A., Li M., Liang Y., Wang Y., Wong L., Chen C., Cheng A., Magdaleno S., Ambion Inc., An Applied Biosytems Business, US

We have developed TaqMan based RT-PCR assays to detect and quantitate siRNAs in vivo. These assays can be used to measure siRNA delivery efficiency after injections and follow body distribution. These assays can also be [...]

Studies of conformational changes induced in a carrier protein: Bovine serum albumin

El Kadi N., Taulier N., Urbach W., Waks M., Paris V, FR

Defective folding diseases have emerged in the last decade as prevalent in an ageing population. In this respect any increased knowledge of folding mechanisms could be crucial for preventing, treating or even curing these neurodegenerative [...]

DNA-Associated Single-walled Carbon Nanotubes as a Platform for Drug Delivery

Dolash B.D., Lahiji R.R., Zemlyanov D.Y., Reifenberger R., Bergstrom D.E., Purdue University, US

DNA-associated single walled carbon nanotubes(DNA:SWCNTs) have shown potential in drug delivery with the ability to translocate across the cell membrane carrying various biomolecules. Our laboratory has completed a series of experiments to show the sonication [...]

Step and Flash Imprint Lithography for the Fabrication of Shape-specific, Enzymatically-triggered, Drug Nanocarriers

Caldorera-Moore M., Glangchai L.C., Shi L., Roy K., The University of Texas at Austin, US

Current concepts in the synthesis of nanocarriers primarily involve the use of polymers or lipids to fabricate self-assembled or emulsion-based particles that are mostly spherical, polydisperse, and release drugs through diffusion or hydrolysis. Although significant [...]

Preparation And Evaluation Of In Vitro Release Of Amphiphilic _-Cyclodextrin Or Pla Nanospheres Containing A Hydrophobic Drug

Lin S., Lahiani-Skiba M., Naouli N., Lahiani-Skiba M., Skiba M., Université de Rouen, FR

Mebendazole (MBZ) is an antihelmintic which belongs to group of benzimidazols. It is used for many intestinal diseases and for other diseases. But its low absorption, its high dosages caused side effects on gastro-intestinal track, [...]

Evaluation of the paromomycin loading characteristics in nanoprecipitated PLGA nanospheres

Kalimouttou S., Lahiani-Skiba M., Naouli N., LIN V.S., Lahiani-Skiba M., Skiba M., Université de Rouen, FR

The aim of this work was to optimize the preparation of poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with paromomycin by a nanoprecipitation technique. PLGA was choosen because of its biodegradability and biocompatibility features. In order to [...]

How much advantage do Nanoscale Phenomena afford for Pulmonary Delivery?

Walji N., Thanou M., Quirke N., Imperial College London, UK

Although claims of improved performance due to nanoscale phenomena are made on a daily basis, exactly how much advantage can be afforded by nanotechnology for specific medical applications is quantitatively unknown. It is generally suggested [...]

Lyceum Chinense and Calcium Phosphate Nanoparticles for Ophthalmic Drug Delivery

He Q., Fang Z., Wang M., Xu Q.W., Chen R., Zhang X.Z., Yaun W.M., Zhau D.M., Wu Jian, Morehouse School of Medicine, US

Glaucoma, the leading cause of irreversible blindness in the world, is estimated to be affected by 67 million people. It is characterized by an increase in intraocular pressure (IOP). Carbonic anhydrase inhibitors (CAIs) are orally [...]